ATP-Sensitive K+ Channel in Rat Liver Mitochondria: Functional Characteristics
Recently, ATP-sensitive potassium (KATP) channel has been described in rat liver mitochondria (Inoue et al., 1991). This channel is blocked not only by ATP but also by the antidiabetic sulfonylurea, glibenclamide, giving evidence that mitochondrial KATP channel may belong to the well known family of ATP-dependent potassium channels found in plasma membranes of cardiac, smooth and skeletal muscle cells (Quast & Cook, 1989), pancreatic B-cells (Petersen & Dunne, 1989) and in the nervous system (Mourre et al., 1990). In B-cells, KATP channels are specifically blocked by sulfonylureas which are the drugs capable to restore insulin secretion in patients affected by non-insulin-dependent diabetes mellitus (Petersen & Dunne, 1989). These channels are also blocked by some of non-sulfonylurea drugs like 8-methoxypsoralen (Szewczyk et al., 1992a) and 8-(N, N-dimethylamino) octyl-3, 4, 5-trimethoxybenzoate (Szewczyk et al., 1992b). KATP channels are activated by hormones such as somatostatin and galanin (De Weille et al., 1988, 1989), free fatty acids (Müller et al., 1992), as well as by K+ channel openers (Cook & Quast, 1990; Duty & Weston, 1990).
KeywordsKATP Channel Mitochondrial KATP Channel KATP Channel Opener Kirin Brewery Nencki Institute
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