ATP-Sensitive K+ Channel in Rat Liver Mitochondria: Functional Characteristics

  • Adam Szewczyk
  • Stawomir Pikuła
  • Lech Wojtczak
  • Maciej J. Nałęczl
Part of the NATO ASI Series book series (volume 83)

Abstract

Recently, ATP-sensitive potassium (KATP) channel has been described in rat liver mitochondria (Inoue et al., 1991). This channel is blocked not only by ATP but also by the antidiabetic sulfonylurea, glibenclamide, giving evidence that mitochondrial KATP channel may belong to the well known family of ATP-dependent potassium channels found in plasma membranes of cardiac, smooth and skeletal muscle cells (Quast & Cook, 1989), pancreatic B-cells (Petersen & Dunne, 1989) and in the nervous system (Mourre et al., 1990). In B-cells, KATP channels are specifically blocked by sulfonylureas which are the drugs capable to restore insulin secretion in patients affected by non-insulin-dependent diabetes mellitus (Petersen & Dunne, 1989). These channels are also blocked by some of non-sulfonylurea drugs like 8-methoxypsoralen (Szewczyk et al., 1992a) and 8-(N, N-dimethylamino) octyl-3, 4, 5-trimethoxybenzoate (Szewczyk et al., 1992b). KATP channels are activated by hormones such as somatostatin and galanin (De Weille et al., 1988, 1989), free fatty acids (Müller et al., 1992), as well as by K+ channel openers (Cook & Quast, 1990; Duty & Weston, 1990).

Keywords

KATP Channel Mitochondrial KATP Channel KATP Channel Opener Kirin Brewery Nencki Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Adam Szewczyk
    • 1
  • Stawomir Pikuła
    • 1
  • Lech Wojtczak
    • 2
  • Maciej J. Nałęczl
    • 1
  1. 1.Department of Muscle BiochemistryNencki Institute of Experimental Biology, Polish Academy of SciencesWarsawPoland
  2. 2.Department of Cellular BiochemistryNencki Institute of Experimental Biology, Polish Academy of SciencesWarsawPoland

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