Stromal Function in Long Term Bone Marrow Culture of Patients with Acute Myeloid Leukemia

  • Michail Ya. Lisovsky
  • Valeri G. Savchenko
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)


Inhibition of normal hemopoiesis-peripheral blood pancytopenia and complete absence of normal colony forming cells in bone marrow [3, 4], is a regular finding in acute (AML) myeloid leukemias [1]. However, this inhibition is reversible. Polyclonal normal hemopoiesis is reestablished in more than two thirds of cases of AML during complete remission, demonstrating the existence of normal stem cells [15]. A few pathogenic mechanisms have been proposed to account for this process: cell crowding, synthesis by leukemic cells of inhibitor substances, cell contact processes and deficiency in the stromal cell microenvironment [2]. Several humoral inhibitors were found to be produced by leukemic cells such as acidic isoferritins, LAI and TNF-alpha [4, 5, 6]. Very little is known about the role of the microenvironment in the inhibition of normal hemopoiesis.


Acute Myeloid Leukemia Bone Marrow Cell Normal Hemopoiesis Normal Bone Marrow Cell Long Term Bone Marrow Culture 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Michail Ya. Lisovsky
    • 1
  • Valeri G. Savchenko
    • 1
  1. 1.Dept. of Hematological Oncology and Bone Marrow TransplantationHematological Research CenterMoscowRussia

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