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Tumor Immunotherapy by IL-2 and IL-2 Gene Transfected Cells

  • A. Lindemann
  • F. M. Rosenthal
  • A. Mackensen
  • H. Veelken
  • P. Kulmburg
  • M. Lahn
  • R. Mertelsmann
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 37)

Abstract

Tumortherapy is based on a variety of treatment modalities. Directly operating cytoreductive approaches are designed to work either locally like surgery or radiotherapy, or systemically like cytotoxic drugs. Other ways of treatment are going to exploit the interaction of tumor and host. They are designed to block the host supply of hormones and growth factors the tumor relies on, to inhibit angiogenesis, or to recruit the intrinsic host defense system. The latter is translated into practice by immunotherapy that has made considerable progress recently. Aside from using monoclonal antibodies against tumor associated antigens (TAA) to mediate tumor cytotoxic effects, various approaches to recruit cytotoxic lymphocytes have been worked out.

Keywords

Renal Cell Carcinoma Minimal Residual Disease Tumor Associate Antigen Autologous Tumor Cell Irradiate Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. Lindemann
    • 1
  • F. M. Rosenthal
    • 1
  • A. Mackensen
    • 1
  • H. Veelken
    • 1
  • P. Kulmburg
    • 1
  • M. Lahn
    • 1
  • R. Mertelsmann
    • 1
  1. 1.Department Medicine I, Hematology and OncologyUniversity of FreiburgGermany

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