Multidrug Resistance in Acute Myelogenous Leukemia: Relevance to Clinical and Laboratory Data
MDR1 gene is responsible for resistance to a number of drugs conventionally used for the treatment of acute myelogenous leukemia in vitro and in vivo [1,2]. The clinical significance of this fact is still obscure. There are no consice clinical data, randomized trials and wide retrospective studies proving the necessity of adding drugs for overcoming MDR1 gene expression to conventional chemotherapy [2,3]. The possible role of other genes involved in cell cycle regulation and apoptosis (myc, p53, c-kit, TGF-beta)on the results of chemotherapy is also discussed . Moreover it was shown that some of the above mentioned genes are mutually regulated .
KeywordsLeukemia Oncol Resis Cyclosporin Etoposide
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