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Reduktion des mikrovaskulären Reperfusionsschadens des Skelettmuskels durch Prostaglandin E1

Reduction of Microvascular Ischemia-Reperfusion Injury of Striated Muscle by Prostaglandin E1

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Book cover Chirurgisches Forum ’94

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume 94))

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Zusammenfassung

Die Aktivierung von Leukozyten und deren Adhärenz am mikrovaskulären Endothel werden als initiale Pathomechanismen für die Entwicklung des mikrovaskulären Reperfusionsschadens nach Ischämie diskutiert [1]. Die dabei freigesetzten toxischen Mediatoren, wie Sauerstoffradikale [1], Leukotriene [2] und Plättchen-aktivierender Faktor (PAF) [3], schädigen die endotheliale Barriere und führen zum interstitiellen Ödem und Gewebeschaden. Experimentelle Untersuchungen weisen darauf hin, daß Prostaglandin E1 (PGE1) den postischämischen Reperfusionsschaden durch Verhinderung der Aktivierung neutrophiler Granulozyten und verminderte Freisetzung toxischer Sauerstoffradikale reduzieren kann [4]. Ziel der Studie war es, den Einfluß von Prostaglandin E1 auf den mikrovaskulären Reperfusionsschaden des Skelettmuskels in vivo quantitativ zu analysieren.

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Literatur

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Author information

Authors and Affiliations

  1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Deutschland

    S. W. Tauber, M. D. Menger & K. Meßmer

  2. Department of Pathology, University of Washington, Seattle, USA

    H.-A. Lehr

  3. Schwarz Pharma AG, Monheim, Deutschland

    P. Ney & U. Mittmann

  4. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, Marchioninistr. 15, D-81366, München, Deutschland

    S. W. Tauber

Authors
  1. S. W. Tauber
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  2. H.-A. Lehr
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  3. P. Ney
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  4. U. Mittmann
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  5. M. D. Menger
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  6. K. Meßmer
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Editor information

Editors and Affiliations

  1. Chirurgische Klinik I, Klinikum der Universität Ulm, Steinhövelstraße 9, D-89075, Ulm, Deutschland

    Hans G. Beger

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© 1994 Springer-Verlag Berlin Heidelberg

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Tauber, S.W., Lehr, HA., Ney, P., Mittmann, U., Menger, M.D., Meßmer, K. (1994). Reduktion des mikrovaskulären Reperfusionsschadens des Skelettmuskels durch Prostaglandin E1 . In: Beger, H.G. (eds) Chirurgisches Forum ’94. Langenbecks Archiv für Chirurgie, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78905-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-78905-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57846-8

  • Online ISBN: 978-3-642-78905-2

  • eBook Packages: Springer Book Archive

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