The Role of Collagenase in Wound Healing
Specific collagenases possess the unique capability of degrading native collagen otherwise resistant to breakdown by all other proteases. in wound healing mesenchymal cells release collagenase irto the extracellular matrix and phagocytic cells lyse collagen, either on their surface or intracellularJy. Coilagenase production is stimulated by interleukin-1, the platelet-derived growth factor (PDCF), and others. Several factors terminate collagenase activity; the most potent is alpha-2-macroglobulin. The best characterized bacterial coJfagenase is produced by Clostridium histolyticum. in contrast to a variety of other clinically tested enzymes, collagenases are the only proteases which can specifically hydrolyze native collagen. Wound healing can be accelerated by enhancement of macrophage chemotaxis due to collagen-derived peptides generated by bacterial collagenase. An increase in macrophage numbers will lead to enhanced cytokine secretion in wounds. In third-degree burn wounds, the event of hypertrophic scarring and scar contracture was markedly reduced in collagenase-treated wounds. Further studies are needed to clarify these effects of collagenase.
KeywordsCollagen Type Hypertrophic Scar Native Collagen Collagenase Activity Scar Contracture
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