Abstract
Brain edema leading to intracranial hypertension is of major concern in cerebral disorders, such as head injury, stroke and brain tumors. Although cerebral tissue water content can be lowered by hypertonic solutions, for example, by mannitol, hypertonic saline, and glycerol, the treatment does not prevent further formation of edema. Methods of treatment may be more beneficial which also ameliorate breakdown of the blood-brain barrier and extravasation of edema fluid. This might be accomplished by inhibition of the formation or release, respectively, of mediator compounds which enhance development and persistence of brain edema.
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© 1994 Springer-Verlag Berlin Heidelberg
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Stoffel, M., Berger, S., Staub, F., Eriskat, J., Baethmann, A. (1994). Posttraumatic Brain Edema: Effects of the Novel Cl- Transport Blocker Torasemide and the Inositol Triphosphate Analogue PP56. In: Bauer, B.L., Brock, M., Klinger, M. (eds) Cerebellar Infarct. Midline Tumors. Minimally Invasive Endoscopic Neurosurgery (MIEN). Advances in Neurosurgery, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78801-7_29
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DOI: https://doi.org/10.1007/978-3-642-78801-7_29
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-57668-6
Online ISBN: 978-3-642-78801-7
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