Abstract
DNA analysis is now widely used in medical and forensic science. As an indicator for the presence of an infectious agent, as a means of detecting mutation associated with an inherited disease gene, or as an individual fingerprint, DNA analysis surpasses all other known tests. The reasons for this are severalfold. Unlike specific proteins, such as the blood group or leucocyte antigens, DNA is found in almost all cells. So that DNA analysis can be carried out on blood, semen and even spittle and hair. In recent years methods have been developed which allow analysis to be carried out on DNA from just a few cells, giving detection sensitivities not available for most molecules. Furthermore, the same reagents and methods can be used with any DNA sample, simplifying laboratory procedures. Finally individual variation in DNA is far greater than in any single phenotypic character.
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© 1994 Springer-Verlag Berlin Heidelberg
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Southern, E.M. (1994). DNA Variation and Its Analysis by Hybridisation to Oligonucleotide Arrays. In: Bär, W., Fiori, A., Rossi, U. (eds) Advances in Forensic Haemogenetics. Advances in Forensic Haemogenetics, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78782-9_19
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DOI: https://doi.org/10.1007/978-3-642-78782-9_19
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