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Type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetes mellitus in BC1[(NODxMus spretus)F1xNOD] mice

  • Conference paper
Autoimmunity: Experimental Aspects

Part of the book series: NATO ASI Series ((ASIH,volume 80))

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Abstract

The nonobese diabetic (NOD), nonobese nondiabetic (NON), cataract Shionogi (CTS), ICR-L-Ishibe (ILI) and ICR-I-Ishibe (III) mouse strains have been used in our experiments. The NOD, NON, CTS and ILI mice were originally derived from outbred Institute of Cancer Research (ICR) mice (Figure 1). One mouse with cataracts and small eyes was found in outbred ICR mice and an inbred cataract Shionogi (CTS) strain characterized by cataracts and microphthalmia was established (Ohtori et al, 1968). Since cataracts are often observed in diabetic patients, two sublines were separated at the sixth generation during the process of establishing the CTS strain according to fasting blood glucose levels; one with euglycemia (fasting blood glucose: approximately 100 mg/dl) and the other with slight hyperglycemia (fasting blood glucose: approximately 150 mg/dl). One female mouse in the former line spontaneously developed diabetes at the 20th generation and the inbred NOD strain was established by selective breeding for diabetes. From the latter line the inbred non-obese nondiabetic (NON) strain was established. More details on the genealogy is described in Ikegami et al, 1988. Inbred ILI and III mice were established directly from outbred ICR mice.

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Authors and Affiliations

  1. Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA, 02215, USA

    Masakazu Hattori, Eiji Yamato, Masahiro Fukuda & Maria Petruzzelli

  2. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, 02142, USA

    Alix Weaver, Armand MacMurray & Eric S. Lander

  3. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, N.Y., 14263, USA

    Verne M. Chapman

Authors
  1. Masakazu Hattori
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  2. Eiji Yamato
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  3. Masahiro Fukuda
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  4. Maria Petruzzelli
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  5. Alix Weaver
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  6. Armand MacMurray
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  7. Eric S. Lander
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  8. Verne M. Chapman
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Editors and Affiliations

  1. Institut Pasteur, 28, rue du Dr. Roux, 75015, Paris, France

    Moncef Zouali

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© 1994 Springer-Verlag Berlin Heidelberg

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Hattori, M. et al. (1994). Type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetes mellitus in BC1[(NODxMus spretus)F1xNOD] mice. In: Zouali, M. (eds) Autoimmunity: Experimental Aspects. NATO ASI Series, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78779-9_22

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  • DOI: https://doi.org/10.1007/978-3-642-78779-9_22

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