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The heavy chain variable region genes of human lupus autoantibodies

  • Conference paper
Autoimmunity: Experimental Aspects

Part of the book series: NATO ASI Series ((ASIH,volume 80))

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Abstract

An important role of the immune system is to distinguish “self” from “non-self” and to act as a first-line of defense against external agents. To cope with the diversity of the potentially antigenic molecules of the environment and those of self-components, the immune system requires a powerful discriminatory ability. In normal conditions, mature B cells respond to antigen stimulation, yet must avoid high-affinity recognition of self-antigens that may lead so aggressive autoimmunity. No mechanism fully accounts for this phenomenon.

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Authors and Affiliations

  1. Laboratoire d’Immunogénétique Cellulaire, Institut Pasteur, 25-28 rue du Dr Roux, 75015, Paris, France

    Christophe Demaison, Patricia Chastagner, Céline Bensimon & Moncef Zouali

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  1. Christophe Demaison
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  2. Patricia Chastagner
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  3. Céline Bensimon
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  4. Moncef Zouali
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Editors and Affiliations

  1. Institut Pasteur, 28, rue du Dr. Roux, 75015, Paris, France

    Moncef Zouali

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© 1994 Springer-Verlag Berlin Heidelberg

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Demaison, C., Chastagner, P., Bensimon, C., Zouali, M. (1994). The heavy chain variable region genes of human lupus autoantibodies. In: Zouali, M. (eds) Autoimmunity: Experimental Aspects. NATO ASI Series, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78779-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-78779-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78781-2

  • Online ISBN: 978-3-642-78779-9

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