Skip to main content
SpringerLink
Log in

Therapie des septischen Kreislaufversagens

  • Chapter
Herz- und kreislaufwirksame Medikamente in Anästhesie, Intensiv- und Notfallmedizin

Part of the book series: Klinische Anästhesiologie und Intensivtherapie ((KAI,volume 47))

  • 28 Accesses

Zusammenfassung

In den USA erleiden jährlich etwa 200000 Patienten einen septischen Schock. 100000 Patienten erliegen diesem Krankheitsbild. Der septische Schock ist damit die häufigste Todesursache auf nordamerikanischen Intensivstationen. Zu diesem Ergebnis kommen die Southwestern Internal Medicine Conference an Septic Shock [9] und das National Institute of Health, das zudem eine stetige Zunahme der Inzidenz des septischen Schocks konstatiert und als mögliche Ursachen die zunehmende Invasivität medizinischer Maßnahmen, den steigenden Anteil älterer und immunsupprimierter Patienten und eine Zunahme multiresistenter Erreger anführt (Abb. 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Astiz ME, Rackow EC, Falk JL, Kaufmann BS, Weil MH (1987) Oxygen delivery and consumption in patients with hyperdynamic septic schock. Crit Care Med 15: 26

    Article  PubMed  CAS  Google Scholar 

  2. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL (1991) Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 99: 956

    Article  PubMed  CAS  Google Scholar 

  3. Bihari D, Smithies M, Gimson A, Tinker J (1987) The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 317: 7

    Article  Google Scholar 

  4. Bollaert PE, Bauer P, Audibert G, Lambert H, Larcan A (1990) Effects of epinephrine on hemodynamics and oxygen metabolism in dopamine-resistant septic shock. Chest 98: 949

    Article  PubMed  CAS  Google Scholar 

  5. Bone RC, Fisher CJ, Clemmer TP (1987) A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317: 653

    Article  PubMed  CAS  Google Scholar 

  6. Broner CW, Shenep JL, Stokes DC, Fairclough D, Hildner WK (1993) Reversal of dopamine-refractory septic shock by diethyldithiocarbamate, an inhibitor of endothelium-derived relaxing factor. J Infect Dis 167: 141

    Article  PubMed  CAS  Google Scholar 

  7. Chernow B, Roth BL (1986) Pharmacologic manipulation of the peripheral vasculature in shock: clinical and experimental approaches. Circ Shock 18: 141

    PubMed  CAS  Google Scholar 

  8. Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA (1987) Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 101: 69

    PubMed  CAS  Google Scholar 

  9. Dal Nogare AR (1991) Southwestern internal medicine conference: septic shock. Am J Med Sci 302: 50

    Article  Google Scholar 

  10. De la Cal MA, Miravalles E, Pascual T, Esteban A, Ruiz-Santana S (1984) Dose-related hemodynamic and renal effects of dopamine in septic shock. Crit Care Med 12: 22

    Article  PubMed  Google Scholar 

  11. Dobb GJ, Faragner EB (1990) The relationship between oxygen uptake and delivery. Intens Care World 7: 131

    Google Scholar 

  12. Doglio GR, Pusajo JF, Egurrola MA, Bonfigli GC, Parra C, Vetere L, Hernandez MS, Fernandez S, Palizas F, Gutierrez G (1991) Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 19: 1037

    Article  PubMed  CAS  Google Scholar 

  13. Edwards JD, Brown GCS, Nightingale P, Slater RM, Faragher EB (1989) Use of survivors’ cardiorespiratory values as therapeutic goals in septic shock. Crit Care Med 17: 1098

    Article  PubMed  CAS  Google Scholar 

  14. Fiddian-Green RG (1992) Tonometry: theory and applications. Intens Care World 9: 60

    CAS  Google Scholar 

  15. Fink MP (1993) Immunotherapy of septic shock. Curr Sci 6: 315

    Google Scholar 

  16. Fong Y, Marano MA, Moldawer LL, Wei H, Calvano SE, Kenney JS, Allison AC, Cerami A, Shires GT, Lowry SF (1990) The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 85: 1896

    Article  PubMed  CAS  Google Scholar 

  17. Gilbert EM, Haupt MT, Mandanas RY, Huaringa AJ, Carlson RW (1986) The effect of fluid loading, blood transfusion, and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis 134: 873

    PubMed  CAS  Google Scholar 

  18. Groeneveld ABJ, Bronsveld W, Lambertus GT (1986) Hemodynamic determinants of mortality in human septic shock. Med Intens Care 99: 140

    CAS  Google Scholar 

  19. Gutierrez G, Palizias F, Doglio G, Wainztein N, Gallesio A, Pacin J, Dubin A, Schiavi E, Jorge M, Pusajo J, Klein F, San Roman E, Dorfman B, Shottlender J, Giniger R (1992) Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 339: 195

    Article  PubMed  CAS  Google Scholar 

  20. Haupt MT, Gilbert EM, Carlson RW (1985) Fluid loading increases oxygen consumption in septic patients with lactic acidosis. Am Rev Respir Dis 131: 912

    PubMed  CAS  Google Scholar 

  21. Kaufmann BS, Rackow EC, Falk JL (1984) The relationship between oxygen delivery and consumption during fluid resuscitation of hypovolemic and septic shock. Chest 85: 336

    Article  Google Scholar 

  22. Li TCM, Phillips MC, Shaw L, Cook EF, Natanson C, Goldman L (1984) On-site physician staffing in a community hospital intensive care unit. JAMA 252: 2023

    Article  PubMed  CAS  Google Scholar 

  23. Lindner KH, Calzia E, Erb J, Georgieff M (1993) Effects of norepinephrine versus phenylephrine on oxygen consumption in septic shock. Crit Care Med 21: 126

    Article  Google Scholar 

  24. Mackenzie SJ, Kapadia F, Mimmo GR, Armstrong IR, Grant IS (1991) Adrenaline in treatment of septic shock: effects on haemodynamics and oxygen transport. Intens Care Med 17: 36

    Article  CAS  Google Scholar 

  25. Martin C, Saux P, Eon E, Aknin P, Gouin F (1990) Septic shock: a goal-directed therapy using volume loading, dobutamine and/or epinephrine. Acta Anaesthesiol Scand 34: 413

    Article  PubMed  CAS  Google Scholar 

  26. Meier-Hellmann A, Hannemann L, Specht M, Spies C, Reinhart K (1993) Lebervenöse and gemischtvenöse 02-Sättigung. Anaesthesie 42: 29

    CAS  Google Scholar 

  27. Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864

    Google Scholar 

  28. Nasraway SA, Rackow EC, Astiz ME, Karras G, Weil MH (1989) Inotropic response to digoxin and dopamine in patients with severe sepsis, cardiac failure and systemic hypoperfusion. Chest 95: 612

    Article  PubMed  CAS  Google Scholar 

  29. Natanson C, Danner RL, Akin GL (1988) Antibiotics, fluids and dopamine in a lethal canine model of septic shock: effects on survival. Clin Res 36: 372

    Google Scholar 

  30. Natanson C, Hoffmann WD, Parrillo JE (1989) Septic shock: the cardiovascular abnormality and therapy. J Cardio Anesth 3: 215

    Article  CAS  Google Scholar 

  31. Nimmo GR, Mackenzie SJ, Walker SW, Catnach J, Nicol M, Armstrong IR, Grant IS (1992) The relationship of blood lactate concentrations, oxygen delivery and oxygen consumption in septic shock and the adult respiratory distress syndrome. Anesthesiology 47: 1023

    CAS  Google Scholar 

  32. Ognibene FP, Parker MM, Natanson C, Shelhamer JH, Parrillo JE (1988) Response to volume infusion in patients with sepsis and septic shock. Chest 93: 903

    Article  PubMed  CAS  Google Scholar 

  33. Palazzo MG, Suter PM (1991) Delivery dependent oxygen consumption in patients with septic shock. Daily variations, relationship with outcome and the sick-euthyroid syndrome. Intens Care Med 17: 325

    Google Scholar 

  34. Parker MM, McCarthy KE, Ognibene FP, Parrillo JE (1990) Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest 97: 126

    Article  PubMed  CAS  Google Scholar 

  35. Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W (1985) Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 76: 1539

    Article  PubMed  CAS  Google Scholar 

  36. Pinsky MR (1993) Oxygen delivery and uptake in septic patients. In: Vincent J-L (ed) Yearbook of intensive care and emergency medicine. Springer, Berlin Heidelberg New York, p373

    Google Scholar 

  37. Rackow EC, Astiz ME (1991) Pathophysiology and treatment of septic shock. JAMA 266: 548

    Article  PubMed  CAS  Google Scholar 

  38. Reinhart K, Hannemann L, Meier-Hellmann A (1991) Sauerstofftransport and Gewebeoxygenierung beim kritisch Kranken - Stellenwert von Volumen and vasoaktiven Substanzen. Klin Wochenschr 69: 112

    Article  PubMed  Google Scholar 

  39. Schremmer B, Dhainaut JF (1990) Heart failure in septic shock: effects of inotropic support. Crit Care Med 18: 49

    Article  Google Scholar 

  40. Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS (1988) Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 94: 1176

    Article  PubMed  CAS  Google Scholar 

  41. Sibbald WJ, Fox G, Martin C (1991) Abnormalities of vascular reactivity in the sepsis syndrome. Chest 100: 155

    Google Scholar 

  42. Silverman HJ, Penaranda R, Orens JB, Lee NH (1993) Impaired ß-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines Crit Care Med 21: 31

    CAS  Google Scholar 

  43. Takala J, Ruokonen E (1992) Oxygen transport in septic shock. Schweiz Med Wochenschr 122: 776

    PubMed  CAS  Google Scholar 

  44. Tuchschmidt J, Fried J, Astiz M, Rackow E (1992) Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 102: 216

    Article  PubMed  CAS  Google Scholar 

  45. Vincent JL, Roman A, Kahn RJ (1990) Dobutamine administration in septic shock: addition to a standard protocol. Crit Care Med 18: 689

    Article  PubMed  CAS  Google Scholar 

  46. Ziegler EJ, McCutchan JA, Fierer J, Glauser MP, Sadoff JC, Douglas H, Braude AI (1982) Treatment of gram-negative bacteremia and shock with human antiserum to a mutant escherichia coli. N Engl J Med 307: 1225

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Reinelt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. H. Lindner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universität Ulm, Steinhövelstr. 9, D-89075, Ulm, USA

    Friedrich Wilhelm Ahnefeld

  2. Klinik für Anästhesiologie, Johannes Gutenberg-Universitä, Langenbeckstr. 1, 55101, Mainz, Deutschland

    Wolfgang Dick

  3. Medizinische Klinik, Innere Medizin III, Universität zu Köln, Joseph-Stelzmann-Str. 9, D-50924, Köln, Deutschland

    E. Erdmann

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Reinelt, H., Lindner, K.H. (1995). Therapie des septischen Kreislaufversagens. In: Ahnefeld, F.W., Dick, W., Erdmann, E. (eds) Herz- und kreislaufwirksame Medikamente in Anästhesie, Intensiv- und Notfallmedizin. Klinische Anästhesiologie und Intensivtherapie, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78777-5_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78777-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57634-1

  • Online ISBN: 978-3-642-78777-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation