Abstract
The impact of local tumor control on overall survival in soft tissue sarcomas is still a point of controversial discussion. Some data indicate the rate of distant metastases to be independent of local tumor control for soft tissue sarcomas (Stotter et al. 1990; Rôôser et al. 1990; Gustafson et al. 1991). However, for a broad variety of tumors Fuks et al. (1991) showed in a comprehensive overview of experimental and clinical data a distinct correlation between local tumor control and the rate of distant metastases/overall survival. This hypothesis was also supported by Suit and Tepper (1986) and Suit (1991). The prognosis of patients with aggressive tumors with a high propensitiy of distant spread is a function of the dissemination rate at diagnosis. As distant spread decreases, local tumor control gradually gains importance as a prognostic factor. For tumors with a low propensitiy of distant spread, local control is the critical determinant for overall survival. Thus, local tumor control is thought to have a varying, but definite impact on overall survival.
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References
Biedermann KA, Sun JR, Giaccia AJ, Tosto LM, Brown JM (1991) Seid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci USA 88:1394–1397
Brown M, Evans J, Kovacs MS (1992) The prediction of human tumor radiosensitivity in situ: an approach using chromosome aberrations detected by fluorescence in situ hybridization. Int J Radiat Oncol Biol Phys 24(2):279–286
Budach V (1991) The role of fast neutron in radiooncology-a critical appraisal. Strahlenther Onkol 167(12):677–692
Budach W, Hartford A, Gioioso D, Freeman J, Taghian A, Suit HD (1992) Tumors arising in SCID mice share the enhanced radiation sensitivity of SCID normal tissues. Cancer Res 52:6292–6296
Dahlberg WK, Little JB, Fletcher JA, Suit HD, Okunief P (1993) Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patient. Int J Radiat Biol 63:191–198
Deschavanne PJ, Debieu D, Fertil B, Malaise EP (1986) Re-evaluation of in vitro radiosensitivity of human fibroblasts of different genetic origins. Int J Radiat Biol 50:279–293
Fletcher GH (1980) Basic clinical parameters. In: Fletcher GH (ed) Textbook of radiotherapy. Lea and Febiger, Philadelphia, pp 180–222
Fuks Z, Leibel SA, Koteher GJ, Mohan R, Ling CC (1991) Three-dimensional conformal treatment: a new frontier in radiation therapy. In: Devita VT Jr, Hellman S, Rosenberg SA (eds) Important advances in oncology. Lippincott, New York, pp 151–171
Gustafson P, Rööser B, Rydholm A (1991) Is local recurrence of minor importance for metastases in soft tissue sarcomas? Cancer 67:2083–2086
Herzberg AJ, Kerns BJ, Honkanen FA, Pence JC, Iglehart JD, Kinney RB (1992) DNA ploidy and proliferation index of soft tissue sarcomas determined by image cytometry of fresh frozen tissue. Am J Clin Pathol 97(5):29–37
Rööser B, Gustafson P, Rydholm A (1990) Is there no influence of local control on the rate of metastases in high-grade soft tissue sarcoma? Cancer 65:1727–1729
Shibamoto Y, Streffer C, Fuhrmann C, Budach V (1991) Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiat Res 128:293–300
Stotter AT, A’Herns RP, Fisher C, Mott AF, Fallowfield ME, Westbury G (1990) The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival. Cancer 65:1119–1129
Stuschke M, Budach V, Klaes W, Sack H (1992) Radiosensitivity, repair capacity, and stem cell fraction in human soft tissue tumors: an in vitro study using multicellular spheroids and the colony assay. Int J Radiat Oncol Biol Phys 23:69–80
Stuschke M, Budach V, Stapper N, Budach W, Dinges S, Sack H (1993a) High stem cell fraction of human gliomas and sarcomas. Int J Radiat Oncol Biol Phys 27 Suppl 1:166
Stuschke M, Budach V, Kalff RL, Sack H, Bamberg M, Reinhardt V, Feldmann HJ (1993b) Spheroid control of malignant glioma cell lines after fractionated irradiation: relation to the surviving fractions at 2 Gy and colony forming efficiencies in a soft agar clonogenic assay. Radiother Oncol 27:245–251
Suit HD (1973) Radiation biology: a basis for radiotherapy. In: Fletcher GH (ed) Textbook of radiology. Lea and Febiger, Philadelphia, pp 75–121
Suit HD (1991) Local control and patient survival: Int J Radiat Oncol Biol Phys 23(3):653–660
Suit HD, Tepper JE (1986) Impact of improved local control on survival in patients with soft tissue sarcoma. Int J Radiat Oncol Biol Phys 12:699–700
Suit HD, Proppe KH, Mankin HJ, Woods WC (1981) Preoperative radiation therapy for sarcomas of soft tissue. Cancer 47:2269–2274
Suit HD, Mankin HJ, Wood WC, Proppe KH (1985) Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer 55:2659–2667
Taghian A, Suit HD, Pardo F, Gioioso D, Tomkinson K, DuBois W, Gerweck L (1992) In vitro intrinsic radiation sensitivity of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 23(l):55–62
Tepper JE, Suit HD (1985) Radiation therapy alone for sarcoma of soft tissue. Cancer 56:475–479
Todoroki T, Suit HD (1985) Therapeutic advantage in pre-operative single dose radiation combined with conservative and radical surgery in different size murine fibrosarcomas. J Surg Oncol 29:207–215
Weichselbaum RR, Beckett MA, Vijayakumar S, Simon MA, Awan AM, Nachman J, Panje WR, Goldman ME, Tybor AG, Moran WJ, Vokes EE, Ahmed-Swan S, Farhangi E (1990) Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy. Int J Radiat Oncol Biol Phys 19(2):313–319
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© 1995 Springer-Verlag Berlin Heidelberg
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Budach, V., Stuschke, M., Budach, W. (1995). Radiosensitivity and Local Tumor Control — Experimental Studies. In: Bamberg, M., Hoffmann, W., Hossfeld, D.K. (eds) Soft Tissue Sarcomas in Adults. Recent Results in Cancer Research, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78768-3_19
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DOI: https://doi.org/10.1007/978-3-642-78768-3_19
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