Regional Hyperthermia Combined with Systemic Chemotherapy of Locally Advanced Sarcomas: Preclinical Aspects and Clinical Results

  • R. D. Issels
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 138)


The combination of anticancer drugs with hyperthermia was recently introduced as a new clinical strategy. This approach within the field of medical oncology is based on the convincing evidence that hyperthermia enhances the therapeutic effect of several chemotherapeutic agents, even in drug-resistant cells. Such a combined modality is of particular interest as a means of overcoming the limited therapeutic efficacy of conventional anticancer agents in the case of large, resistant human tumors. As many readers may not be familiar with the current status of hyperthermia in the context of chemotherapy, a brief overview will be given. Related to our clinical results using regional hyperthermia (RHT) combined with systemic chemotherapy in soft tissue sarcoma, active single agents will first be defined and preclinical data on their potential for thermochemotherapy including several other drugs will be summarized.


Soft Tissue Sarcoma Systemic Chemotherapy Chinese Hamster Ovary Cell Regional Hyperthermia Advanced Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • R. D. Issels
    • 1
  1. 1.Medizinische Klinik III, Klinikum GroßhadernLudwig-Maximilians-Universität and GSF-Institute of Clinical Haematology MünchenMünchenGermany

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