Structural Plasticity of Primary Afferent Terminals in the Adult Dorsal Horn — Regenerative Sprouting Induced by Peripheral Nerve Injury

  • Clifford J. Woolf
Conference paper
Part of the NATO ASI Series book series (volume 79)


This chapter will review evidence that a structural reorganization of the central terminals of axotomized primary afferents contributes to the pathogenesis of peripheral neuropathic pain. Peripheral neuropathic or neurogenic pain is that pain resulting from a lesion to or disorder of the peripheral nervous system and includes a number of diverse conditions, the commonest of which are; trigeminal neuralgia, postherpetic neuralgia, painful diabetic neuropathy, the reflex sympathetic dystrophies, mononeuropathies and peripheral nerve injury. Patients typically present with a characteristic set of sensory disorders; a constant burning pain, a partial loss of sensitivity, tactile or cold allodynia (the production of pain in response to low intensitiy stimuli) and hyperpathia (abnormal painful sensations) with repeated stimulation.


Dorsal Root Ganglion Neuropathic Pain Sciatic Nerve Dorsal Horn Peripheral Nerve Injury 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Clifford J. Woolf
    • 1
  1. 1.Department of Anatomy and Developmental BiologyUniversity College LondonLondonUK

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