Hyperexcitabilty in the Spinal Dorsal Horn: Cooperation of Neuropeptides and Excitatory Amino Acids

  • Laszlo Urban
  • Stephen W. N. Thompson
  • Istvan Nagy
  • Andy Dray
Conference paper
Part of the NATO ASI Series book series (volume 79)


There is a large body of evidence showing that during hyperalgesia both nociceptive specific (NS) and wide dynamic range neurons (WDR) in the spinal dorsal horn become hyperexcitable (see Coggeshall and Willis73). Increased spike discharge and/or sustained membrane depolarization evoked by peripheral stimulation have been used as the measure of this hyperexcitability and this has been described following acute complete Freund’s adjuvant (CFA)-induced arthritis or skin inflammation59,63 and in chemically evoked inflammation.14,27


NMDA Receptor Dorsal Horn Excitatory Amino Acid Spinal Dorsal Horn Dorsal Horn Neuron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Laszlo Urban
    • 1
  • Stephen W. N. Thompson
    • 1
  • Istvan Nagy
    • 1
    • 2
  • Andy Dray
    • 1
  1. 1.Department of PharmacologySandoz Institute for Medical ResearchLondonUK
  2. 2.Dept. Anat.Univ. Med. School of DebrecenHungary

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