TRH and Substance P Increase Rat Motoneurone Excitability through a Block of a Novel K+ Conductance

  • A. Nistri
  • N. D. Fisher
  • G. Baranauskas
Conference paper
Part of the NATO ASI Series book series (volume 79)


Immunocytochemical studies of the fine localization of endogenously-occurring TRH and substance P in the mammalian spinal cord have shown that these two peptides are present in the terminals of fibres descending from the raphe nucleus and which establish synaptic contacts with the proximal dendrites of motoneurons.1,7. Other nerve cells containing these peptides are found in the spinal dorsal horn.


Reversal Potential Input Resistance Spinal Dorsal Horn Current Clamp Tachykinin Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Nistri
    • 1
  • N. D. Fisher
    • 1
  • G. Baranauskas
    • 1
  1. 1.Biophysics SectorInternational School for Advanced Studies (SISSA)TriesteItaly

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