RNA polymerase III

Genes, factors and transcriptional specificity
  • Ian M. Willis
Part of the EJB Reviews book series (EJB REVIEWS, volume 1993)

Abstract

Recent studies on RNA polymerase III (pol III) gene transcription have provided a new awareness of the molecular complexity of this process. Fortunately, while the number of transcription components has been increasing, fundamental similarities have emerged regarding the function of eukaryotic promoter elements and the factors that bind them to form preinitiation complexes. Among these, the ability of transcription factor IIIB (TFIIIB) and pol III to transcribe the Saccharomyces cerevisiae U6 gene suggests that the concept of a minimal pol II promoter comprising a TATA box and an initiator region has a parallel in the pol III system. Furthermore, for each of the three classes of eukaryotic RNA polymerase, the assembly of transcription preinitiation complexes and, to some extent, the nature of these complexes appears to be more similar than was previously anticipated.

Keywords

Migration Glycerol Cysteine Heparin Sedimentation 

Abbreviations

TF

transcription factor

TBP

TATA-binding protein

PSE

proximal sequence element

DSE

distal sequence element

EBER

Epstein-Barr virus-encoded RNA

ETAB

EBER TATA box

ATF

activating transcription factor

NC

negative cofactor

PBP

proximal element-binding protein

PTF

PSE transcription factor

pol

polymerase

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Copyright information

© Federation of European Biochemical Societies 1994

Authors and Affiliations

  • Ian M. Willis
    • 1
  1. 1.Department of Biochemistry, Albert Einstein College of MedicineJack and Pearl Resnick CampusBronxUSA

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