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Chronobiology in Hemostastis

  • Chapter
Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

Arterial and venous thromboembolic disorders remain the leading cause of death in most of the develop countries. A thrombotic occlusion of a coronary or cerebral artery, already damaged by atherosclerosis, appears to be a common and essential link in the onset of most of the cases of such vascular events and induces myocardial or cerebral infarctions [1, 2]. It is not surprising, therefore, that these vascular disorders and the hemostatic system are correlated. For example, high levels of plasma fibrinogen and factor VII coagulant activity were associated with an increased risk of death from cardiovascular disease [3]. High plasma levels of the fast-acting plasminogen activator inhibitor (PAI-1) seem also to be correlated with acute coronary thrombosis [4]. In venous thrombosis the relationship between the disease and the hemostatic system is even more patent. Thus, biological rhythms which modulate the hemostatic system are expected to relate to temporal changes in the incidence of thromboembolic disorders. Such rhythms may also induce temporal variations in the biological effect of antithrombotic agents. Possible therapeutic implications of these observations for the treatment of thromboembolic disorders deserve to be considered and evaluated.

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  1. H. Decousus
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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Decousus, H. (1992). Chronobiology in Hemostastis. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_40

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_40

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