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Biogenesis of Neurosecretory Vesicles

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Glyco-and Cellbiology

  • 44 Accesses

Abstract

Neurosecretory vesicles are defined as the vesicles which mediate the usually calcium-dependent, regulated release of signaling molecules in the nervous system. At least two types of neurosecretory vesicles can be distinguished by their structure and content. The first type are the synaptic vesicles of neurons, which mediate the storage and release of classical neurotransmitters (e.g., acetylcholine, glutamate, GABA, and glycine) but lack secretory proteins. Synaptic vesicles have a counterpart in certain endocrine cells, the synaptic-like microvesicles (SLMVs). The second type are the large dense core vesicles of neurons, which mediate the storage and release of neuropeptides. These vesicles are the neuronal equivalent of the secretory granules found in cells capable of regulated protein secretion, notably endocrine cells. (Since large dense cote vesicles are essentially similar, if not identical, to endocrine secretory granules, we shall also use the term “secretory granules” when refering to large dense core vesicles of neurons.) This chapter summarizes recent data obtained in our laboratory concerning the biogenesis of secretory granules from the trans-Golgi network (TGN) and of SLMVs from early endosomes in the neuroendocrine cell line PC12.

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Author information

Author notes

  1. H.-H. Gerdes

    Present address: Institute for Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany

  2. F. A. Barr

    Present address: National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK

  3. E. Chanat

    Present address: Laboratoire de Biologie Cellulaire et Moléculaire, INRA, F-78352, Jouy-en-Josas Cédex, France

  4. A. Leyte

    Present address: The Netherland Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

  5. A. Régnier-Vigouroux

    Present address: Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, F-13288, Marseille Cédex 9, France

  6. T. Flatmark

    Present address: Department of Biochemistry, University of Bergen, N-5009, Bergen, Norway

  7. P. Rosa

    Present address: Department of Pharmacology, School of Medicine, CNR Center of Cytopharmacology, Via Vanvitelli 32, I-20129, Milan, Italy

  8. S. A. Tooze

    Present address: European Molecular Biology Laboratory, Meyerhofstr. 1, D-69117, Heidelberg, Germany

Authors and Affiliations

  1. Institute for Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D-69120, Heidelberg, Germany

    W. B. Huttner, R. Bauerfeind, O. Bräunling & M. Ohashi

Authors
  1. W. B. Huttner
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  2. F. A. Barr
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  3. R. Bauerfeind
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  4. O. Bräunling
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  5. E. Chanat
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  6. A. Leyte
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  7. M. Ohashi
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  8. A. Régnier-Vigouroux
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  9. T. Flatmark
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  10. H.-H. Gerdes
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  11. P. Rosa
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  12. S. A. Tooze
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Editor information

Editors and Affiliations

  1. Institut für Biochemie I der Universität, Universität Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany

    Felix Wieland

  2. Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-14195, Berlin, Germany

    Werner Reutter

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© 1994 Springer-Verlag Berlin Heidelberg

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Huttner, W.B. et al. (1994). Biogenesis of Neurosecretory Vesicles. In: Wieland, F., Reutter, W. (eds) Glyco-and Cellbiology. Colloquium der Gesellschaft für Biologische Chemie 22.–24. April 1993 in Mosbach/Baden, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78729-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-78729-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78731-7

  • Online ISBN: 978-3-642-78729-4

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