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Function of Molecular Chaperones in Protein Folding

  • F. U. Hartl
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 22.–24. April 1993 in Mosbach/Baden book series (MOSBACH, volume 44)

Abstract

How a newly synthesized polypeptide chain acquires its specific three-dimensional structure is a fundamental problem in biology. Only in recent years, however, have cell biologists and physical biochemists turned their attention to the process of protein folding as it occurs in vivo. As a result, the long-held view that proteins in the cell fold in a largely spontaneous process has been called into question.

Keywords

Molecular Chaperone Ribulose Bisphosphate Folding Intermediate Protein DnaJ Nascent Polypeptide Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • F. U. Hartl
    • 1
  1. 1.Rockefeller Reserach LaboratoriesSloan-Kettering InstituteNew YorkUSA

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