Function of Molecular Chaperones in Protein Folding

  • F. U. Hartl
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 22.–24. April 1993 in Mosbach/Baden book series (MOSBACH, volume 44)


How a newly synthesized polypeptide chain acquires its specific three-dimensional structure is a fundamental problem in biology. Only in recent years, however, have cell biologists and physical biochemists turned their attention to the process of protein folding as it occurs in vivo. As a result, the long-held view that proteins in the cell fold in a largely spontaneous process has been called into question.


Molecular Chaperone Ribulose Bisphosphate Folding Intermediate Protein DnaJ Nascent Polypeptide Chain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • F. U. Hartl
    • 1
  1. 1.Rockefeller Reserach LaboratoriesSloan-Kettering InstituteNew YorkUSA

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