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Glyco-and Cellbiology pp 161–169Cite as

The Biologic Significance of Glycoprotein Hormone Oligosaccharides

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Abstract

The glycoprotein hormones lutropin (LH), follitropin (FSH), thyrotropin (TSH), and chorionic gonadotropin (CG) are dimeric proteins. They consist of a common a subunit and highly homologous, but hormone-specific, β subunits (Fig. 1). Even though the structures of the glycoprotein hormones are closely related at the primary, secondary, and tertiary levels, the structures of their Asn-linked oligosaccharides differ. LH and TSH bear oligosaccharides which terminate with the unique sequence SO44GalNAcβ1, 4GlcNAcβ1, 2Manα (S4GGnM) whereas FSH and CG bear oligosaccharides which terminate with the sequence sialic acid α2, 3/6Galβ1, 4GlcNAcβ1, 2Manα (Baenziger and Green 1991; Green and Baenziger 1988a, b; Green et al. 1985b; Endo et al. 1979; Mizuochi and Kobata 1980). The synthesis of these sulfated oligosaccharides reflects the activity of two highly specific enzymes, a GalNAc-transferase and a sulfotransferase.

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References

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Authors and Affiliations

  1. Department of Pathology, Washington University School of Medicine, 63110, St. Louis, MO, USA

    J. U. Baenziger

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  1. J. U. Baenziger
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Editors and Affiliations

  1. Institut für Biochemie I der Universität, Universität Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany

    Felix Wieland

  2. Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-14195, Berlin, Germany

    Werner Reutter

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© 1994 Springer-Verlag Berlin Heidelberg

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Baenziger, J.U. (1994). The Biologic Significance of Glycoprotein Hormone Oligosaccharides. In: Wieland, F., Reutter, W. (eds) Glyco-and Cellbiology. Colloquium der Gesellschaft für Biologische Chemie 22.–24. April 1993 in Mosbach/Baden, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78729-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-78729-4_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78731-7

  • Online ISBN: 978-3-642-78729-4

  • eBook Packages: Springer Book Archive

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