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Use of Mechanistic Information in Risk Assessment pp 151–160Cite as

The role of mechanistic studies in understanding target organ toxicity

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Part of the book series: Archives of Toxicology, Supplement 16 ((TOXICOLOGY,volume 16))

Abstract

The approach to understanding the mechanism whereby a chemical produces toxicity has been described in some detail by Aldridge (1986). He discussed the toxic process in terms of a series of related events which occur following the entry of a toxic chemical into the body. These key conponents include:- (1) all systems that influence the delivery of the chemical or its metabolically derived toxic metabolite(s) to its target site(s) of action; (2) the interaction of the proximate toxin with critical cellular conponents which are comranly, but not exclusively, macromolecules; (3) the initiation of a sequence or cascade of biochemical and physiological events that follows the earlier primary events(s) and (4) the consequences to the target organ that are seen as clinical signs or synptoms which may vary depending on the target organ or organs damaged.

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Author information

Authors and Affiliations

  1. Research Toxicology Section, Zeneca Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK

    Edward A. Lock

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  1. Edward A. Lock
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Editor information

Editors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Hermann M. Bolt

  2. Department of Occupational Medicine, Uppsala University Hospital, S-75185, Uppsala, Sweden

    Björn Hellman

  3. Department of Pharmaceutical Biosciences: Toxicology, BMC, Uppsala University, Box 594, S-75124, Uppsala, Sweden

    Lennart Dencker

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© 1994 Springer-Verlag Berlin Heidelberg

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Lock, E.A. (1994). The role of mechanistic studies in understanding target organ toxicity. In: Bolt, H.M., Hellman, B., Dencker, L. (eds) Use of Mechanistic Information in Risk Assessment. Archives of Toxicology, Supplement 16, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78640-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-78640-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78642-6

  • Online ISBN: 978-3-642-78640-2

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