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Newer Approaches to the Evaluation of Sensitization Phenomena

  • Conference paper
Use of Mechanistic Information in Risk Assessment

Part of the book series: Archives of Toxicology, Supplement 16 ((TOXICOLOGY,volume 16))

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Abstract

Sensitization is the imnunological process whereby an individual is rendered hypersensitive to a particular allergen. Allergic reactions develop usually in two stages. Following first encounter with the inducing allergen the susceptible individual mounts a specific immune response which results in sensitization. Subsequent exposure to the same allergen provokes an accelerated and more aggressive response which in turn causes adverse health effects; the most common of which in the context of industrial toxicology and occupational medicine are allergic contact dermatitis and respiratory hypersensitivity.

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Author information

Authors and Affiliations

  1. ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK

    I. Kimber

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  1. I. Kimber
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Editor information

Editors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Hermann M. Bolt

  2. Department of Occupational Medicine, Uppsala University Hospital, S-75185, Uppsala, Sweden

    Björn Hellman

  3. Department of Pharmaceutical Biosciences: Toxicology, BMC, Uppsala University, Box 594, S-75124, Uppsala, Sweden

    Lennart Dencker

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© 1994 Springer-Verlag Berlin Heidelberg

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Kimber, I. (1994). Newer Approaches to the Evaluation of Sensitization Phenomena. In: Bolt, H.M., Hellman, B., Dencker, L. (eds) Use of Mechanistic Information in Risk Assessment. Archives of Toxicology, Supplement 16, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78640-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-78640-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78642-6

  • Online ISBN: 978-3-642-78640-2

  • eBook Packages: Springer Book Archive

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