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Mechanisms of Plaque Formation and Occlusion in Venous Coronary Bypass Grafts

  • Chapter
Coronary Artery Graft Disease

Abstract

The progression of venous coronary bypass graft disease can be divided into three phases [12]: (a) acute thrombotic phase, (b) intimai hyperplasia, and (c) atherosclerosis (Fig. 1). Acute thrombotic occlusion occurs within the first month after operation and is mediated mainly by platelets. Between 1 and 12 months after operation smooth muscle cells begin to proliferate, and connective tissue synthesis increases. After 3 years atherosclerotic lesions progress further, and the natural history of venous bypass grafts becomes similar to that of native coronary arteries with advanced atherosclerosis.

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Authors
  1. I. K. Jang
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  2. V. Fuster
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Editor information

Editors and Affiliations

  1. Abteilung Kardiologie, Inselspital, 3010, Bern, Switzerland

    Thomas F. Lüscher

  2. Herz-Gefäßchirurgie, Universitätsspital, 8091, Zürich, Switzerland

    Marko Turina

  3. Department of Medicine, Harvard University and Brigham and Women’s Hospital, Boston, MA, 02115-6195, USA

    Eugene Braunwald

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© 1994 Springer-Verlag Berlin Heidelberg

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Jang, I.K., Fuster, V. (1994). Mechanisms of Plaque Formation and Occlusion in Venous Coronary Bypass Grafts. In: Lüscher, T.F., Turina, M., Braunwald, E. (eds) Coronary Artery Graft Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78637-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-78637-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78639-6

  • Online ISBN: 978-3-642-78637-2

  • eBook Packages: Springer Book Archive

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