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Shigella flexneri: Genetics of Entry and intercellular Dissemination in Epithelial Cells

  • Chapter
Bacterial Pathogenesis of Plants and Animals

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 192))

Abstract

A century ago, Shiga isolated the etiologic agent of bacillary dysentery (SHIGA 1898) . The genus Shigella is now divided into four species, S. boydii, S. dyseriteriae, S. flexneri, and S. sonnei. Shigellosis, whose clinical signs range from mild diarrhea to severe dysentery with blood, mucus, and pus in the stool, remains endemic throughout the world. Epidemiological studies indicate that Shigella is transmitted by the fecal-oral route and sometimes by contaminated food (WHARTON et al. 1990). Shigella are highly infectious organisms for humans, since only a few hundred bacteria administered orally caused disease in 50% of volunteers (DUPONT et al. 1989).

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  1. Unité de Pathogénie Microbienne Moléculaire et Unité INSERM 199, Institut Pasteur, 28 Rue du Dr Roux, 75724, Paris Cedex, France

    C. Parsot

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  1. Max-Delbrück-Laboratory, Carl-von-Linné-Weg 10, 50829, Cologne, Germany

    Jeffery L. Dangl

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Parsot, C. (1994). Shigella flexneri: Genetics of Entry and intercellular Dissemination in Epithelial Cells. In: Dangl, J.L. (eds) Bacterial Pathogenesis of Plants and Animals. Current Topics in Microbiology and Immunology, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78624-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-78624-2_10

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