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Measles Virus Strain Variations

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Measles Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 191))

Abstract

Measles virus is monotypic in nature, i.e. only a single serotype of the virus has been described. Thus, until recently, little emphasis has been placed on variation between MV strains, except for those associated with a rare neurological complication, subacute sclerosing panencephalitis (SSPE), associated with a persistent MV infection. In this chapter, we review variations between MV strains. Biological differences as well as biochemical and nucleotide sequence differences have been documented, but so far the latter have not been correlated with any specific phenotype of the virus. The structure and gene expression strategy of the virus are reviewed elsewhere in this volume (see chapter by Horikami and Moyer, this volume).

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References

  • Baczko K, Brinckmann U, Pardowitz I, Rima BK, ter Meulen V (1991) Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains. J Gen Virol 72: 2279–2282

    Article  PubMed  CAS  Google Scholar 

  • Baczko K, Pardowitz I, Rima BK, ter Meulen V (1992) Constant and variable regions of measles virus proteins encoded by the nucleocapsid and phosphoprotein genes derived from lytic and persistent viruses. Virology 190: 469–474

    Article  PubMed  CAS  Google Scholar 

  • Baczko K, Lampe J, Liebert UG, ter Meulen V, Pardowitz I, Budka H, Cosby SL, Isserte S, Rima BK (1993) Clonal expansion of hypermutated measles virus in a SSPE brain. Virology 197: 188–195

    Article  PubMed  CAS  Google Scholar 

  • Bass BL, Weintraub H, Cattaneo R Billeter MA (1989) Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double stranded RNA. Cell 58: 33

    Google Scholar 

  • Bellini WJ, Englund G, Rozenblatt S, Arnheiter H, Richardson CD (1985) Measles virus P gene codes for two proteins. J Virol 53: 908–919

    PubMed  CAS  Google Scholar 

  • Bellini WJ, Englund G, Richardson CD, Rozenblatt S, Lazzarini RA (1986) Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences, and deduced amino acid sequences. J Virol 58: 408–416

    PubMed  CAS  Google Scholar 

  • Bergholz CM, Kiley MP, Payne FE (1975) Isolation and characterization of temperature-sensitive mutants of measles virus. J Virol 16: 192–202

    PubMed  CAS  Google Scholar 

  • Breschkin AM, Haspel MV, Rapp F (1976) Neurovirulence and induction of hydrocephalus with parental, mutant and revertant strains of measles virus. J Virol 18: 809–811

    PubMed  CAS  Google Scholar 

  • Buckland R, Gerald C, Barker R, Wild TF (1987) Fusion glycoprotein of measles virus: nucleotide sequence of the gene and comparison with other paramyxoviruses. J Gen Virol 68: 1695–1763

    Article  PubMed  CAS  Google Scholar 

  • Calain P, Roux L (1988) Generation of measles virus defective interfering particles and their presence in a preparation of attenuated live virus vaccine. J Virol 62: 2859–2866

    PubMed  CAS  Google Scholar 

  • Cane PA, Pringle CR (1991) Respiratory syncytial virus heterogenuity during an epidemic: analysis by limited nucleotide sequencing (SH gene) and restriction mapping (N gene). J Gen Virol 72: 349–357

    Article  PubMed  CAS  Google Scholar 

  • Carabana J, Caballero M, Ortego J, Fernandez-Munoz R, Celma ML (1993) Mutation patterns in measles virus envelop proteins from two subacute sclerosing panencephalitis brains of contemporary patients with the same geographical origin. Abstracts of the IXth international congress of virology, Glasgow Scotland. p 295

    Google Scholar 

  • Carrigan D (1986) Round cell variant of measles virus: neurovirulence and pathogenesis of acute encephalitis in new born hamsters. Virology 148: 349–359

    Article  PubMed  CAS  Google Scholar 

  • Cattaneo R, Rebmann G, Schmid A, Baczko K, ter Meulen V, Bellini WJ, Rozenblatt S, Billeter MA (1986) Accumulated measles virus mutations in a case of subacute sclerosing panencephalitis: interrupted matrix protein reading frame and transcription attenuation. Virology 154: 97–107

    Article  PubMed  CAS  Google Scholar 

  • Cattaneo R, Schmid A, Eschle D, Baczko K, ter Meulen V, Billeter MA (1988a) Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell 55: 255–265

    Article  PubMed  CAS  Google Scholar 

  • Cattaneo R, Schmid A, Billeter MA, Sheppard RD, Udem SA (1988b) Multiple viral mutations rather than host factors cause defective measles virus gene expression in a subacute sclerosing panencephalitis cell line. J Virol 62: 1388–1397

    PubMed  CAS  Google Scholar 

  • Cattaneo R, Schmid A, Spielhofer P, Kaelin K, Baczko K, ter Meulen V, Pardowitz I, Flanagan S, Rima BK, Udem SA, Billeter MA (1989) Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173: 415–425

    Article  PubMed  CAS  Google Scholar 

  • Chui L W-L, Vainionpää R, Marusyk R, Salmi A Norrby E (1986) Nuclear accumulation of measles virus nucleoprotein associated with a temperature-sensitive mutant. J Gen Virol 67: 2153–2161

    Article  PubMed  CAS  Google Scholar 

  • Döring RE, Marcil A, Chopra A, Richardson C (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75: 295–305

    Article  Google Scholar 

  • Ecker A, ter Meulen V, Schneider-Schaulies S (1994) Differentiation dependent regulation of unwinding/ modifying activity for measles virus in neural cells (submitted for publication)

    Google Scholar 

  • Galinski MS (1991) Annotated nucleotide and protein sequences for selected Paramyxoviridae. In: Kingsbury DW (eds) The paramyxoviruses. Plenum, New York, pp 537–588

    Google Scholar 

  • Giraudon P, Jacquier MF, Wild TF (1988) Antigenic analysis of African measles field isolates: identification and localisation of one conserved and two variable epitope sites on the NP protein. Virus Res 10: 137–153

    Article  PubMed  CAS  Google Scholar 

  • Gould EA, Cosby SL, Shirodaria PV (1976) Salt dependent haemagglutinating measles virus in SSPE. J Gen Virol 33: 139–142

    Article  PubMed  CAS  Google Scholar 

  • Haspel MV, Duff R, Rapp F (1975) Isolation and preliminary characterization of temperature-sensitive mutants of measles virus. J Virol 16: 1000–1009

    PubMed  CAS  Google Scholar 

  • Holland JK, Spindler F, Horodyski E, Graham S, Nichol S, VanDePol S (1982) Rapid evolution of RNA genomes. Science 215: 1577–1585

    Article  PubMed  CAS  Google Scholar 

  • Horta-Barbosa L, Hamilton R, Wittig B, Fucillo DA, Sever JI, Vernon ML (1971) Subacute Sclerosing Panencephalitis: isolation of suppressed measles virus from lymph node biopsy. Science 173: 840–841

    Article  PubMed  CAS  Google Scholar 

  • Hu A, Sheshberadaran H, Norrby E, Kövamees J (1993) Molecular characterisation of epitopes on the measles virus hemagglutinin protein. Virology 192: 351–354

    Article  PubMed  CAS  Google Scholar 

  • Hull JD, Krah DL, Choppin PW (1987) Resistance of measles virus mutant to fusion inhibitory oligopeptides is not associated with mutations in the fusion peptide. Virology 159: 368–372

    Article  PubMed  CAS  Google Scholar 

  • Lieber UG, Flanagan SG, Löffler S, Baczko K, ter Meulen V, Rima BK (1994) Definition of antigenic determinants in the haemagglutinin of measles virus important for neurotropism and neurovirulence. J Virol 68: 1486–1493

    Google Scholar 

  • Lisewski MK, Atkinson JP (1992) Membrane cofactor protein. In: Parker CJ (ed) Membrane defenses against attack by complement and perforins. Springer, Berlin Heidelberg New York pp 45–60 (Current topics in microbiology and immunology, vol 178)

    Chapter  Google Scholar 

  • McKimm J, Rapp F (1977) Variation in ability of measles virus plaque progeny to induce interferon. Proc Natl Acad Sci USA 74: 3056–3059

    Article  PubMed  CAS  Google Scholar 

  • Mori T, Sasaki K, Hashimoto H, Makino S (1993) Molecular cloning and complete nucleotide sequence of genomic RNA of the AIK-c strain of attenuated measles virus. Virus Genes 7: 67–81

    Article  PubMed  CAS  Google Scholar 

  • Naniche D, Varior-Krishnan G, Cervoni F, Wild F, Rossi B, Rabourdin-Combe C, Gerlier D (1993) Human membrane cofactor protein (CD46) acts as the cellular receptor for measles virus. J Virol 67: 6025–6032

    PubMed  CAS  Google Scholar 

  • Ragar-Zisman B, Egan JE, Kress Y, Bloom BR (1984) Isolation of cold-sensitive mutants of measles virus from persistently infected murine neuroblastoma cells. J Virol 51: 845–855

    Google Scholar 

  • Rapp F (1964) Plaque differentiation and replication of virulent and attenuated strains of measles virus. J Bacteriol 88: 1448–1458

    PubMed  CAS  Google Scholar 

  • Rataul SM, Hirano A, Wong TC (1992) Irreversible modification of measles virus RNA in vitro by nuclear-unwinding activity in human neuroblastoma cells. J Virol 66: 1769–1773

    PubMed  CAS  Google Scholar 

  • Richardson CD, Scheid A, Choppin PW (1980) Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the Fl on HA2 viral polypeptides. Virology 105: 205–222

    Article  PubMed  CAS  Google Scholar 

  • Richardson CD, Hull D, Greer P, Hasel K, Berkovich A, Englund G, Bellini WJ, Rima BK, Lazzarini RA (1986) The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston strain): a comparison of fusion proteins from several different paramyxoviruses. Virology 155: 508–523

    Article  PubMed  CAS  Google Scholar 

  • Rima BK (1989) Comparison of amino acid sequences of the major structural proteins of the paramyxoand morbilliviruses. In: Kolakofsky D, Mahy BWJ (eds) Genetics and Pathogenicity of Negative Strand Viruses. Elsevier, Amsterdam, pp 254–262

    Google Scholar 

  • Rima BK (1994) The Pathogenesis of Subacute Sclerosing Panencephalitis. Rev Med Virol 4: 81–90

    Article  CAS  Google Scholar 

  • Rima BK, Davidson WB, Martin SJ (1977) The role of defective interfering particles in persistent infection of Vero cells by measles virus. J Gen Virol 35: 89–97

    Article  PubMed  CAS  Google Scholar 

  • Rima BK, Martin SJ, Gould EA (1979) A comparison of polypeptides in measles and SSPE virus strains. J Gen Virol 42: 603–608

    Article  PubMed  CAS  Google Scholar 

  • Rota JS, Humel KB, Rota PA, Bellini WJ (1992) Genetic variability of the glycoprotein genes of current wild type measles isolates. Virology 188: 135–142

    Article  PubMed  CAS  Google Scholar 

  • Rota JS, De-Wang Z, Rota PA, Bellini WJ (1994) Comparison of sequences of the H, F and N coding genes of measles virus vaccine strains. Virus Res 31: 317–330

    Article  PubMed  CAS  Google Scholar 

  • Rota PA, Bloom AE, Vanchier JA, Bellini WJ (1994) Evolution of the nucleoprotein and matrix genes of wild-type strains of measles virus isolated from recent epidemics. Virology 198: 724–730

    Article  PubMed  CAS  Google Scholar 

  • Rozenblatt S, Eizenberg 0, Ben-Levy R, Lavie V, Bellini WJ (1985) Sequence homology within the morbilliviruses. J Virol 53: 684–690

    PubMed  CAS  Google Scholar 

  • Saito H, Sato H, Abe M, Harata S, Amano K, Suto T, Morita M (1992) Isolation and characterization of measles virus strains with low hemagglutination activity. Intervirology 33: 57–60

    PubMed  CAS  Google Scholar 

  • Sakata H, Kobune F, Sato TA, Tanabayashi K, Yamada A, Sigiura A (1993) Variation in field isolates of measles virus during an 8-year period in Japan. Microbiol lmmunol 37: 233–237

    CAS  Google Scholar 

  • Schmid A, Spielhofer P, Cattaneo R, Baczko K, ter Meulen V, Billeter MA (1992) Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus. Virology 188: 910–915

    Article  PubMed  CAS  Google Scholar 

  • Sheppard RD, Raine CS, Bomstein MB, Udem SA (1986) Rapid degradation restricts measles virus matrix protein expression in a subacute sclerosing panencephalitis cell line. Proc Natl Acad Sci USA 83: 7913–7917

    Article  PubMed  CAS  Google Scholar 

  • Sheshberadaran H, Chen SN, Norrby E (1983) Monoclonal antibodies against five structural components of measles virus: I: characterisation of antigenic determinants on nine strains of measles virus. Virology 128: 341–353

    Article  PubMed  CAS  Google Scholar 

  • Shirodaria PV, Dermott SE, Gould EA (1976) some characteristics of salt-dependent haemagglutinating measles virus. J Gen Virol 33: 107–115

    Article  PubMed  CAS  Google Scholar 

  • Suzuki K, Morita H, Katoh M, Kidokoro M, Saika S, Yoshizawa S, Hashizume S, Horiuchi K, Okabe N, Shinozaki T, Hirayama M (1990) Development and evaluation of the TD97 measles virus vaccine. J Med Virol 32: 194–201

    Article  PubMed  CAS  Google Scholar 

  • Taylor MJ, Godfrey E, Baczko K, ter Meulen V, WildTF, Rima BK (1991) Identification of several different lineages of measles virus. J Gen Virol 72: 443–447

    Article  Google Scholar 

  • Van Wyke Coelingh KL, Winter CC, Murphy BR (1988) Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza virus isolated from 1957 to 1983. Virology 162: 137–143

    Article  Google Scholar 

  • Vydelingum S, lIonen J, Salonen R, Marusyk R, Salmi A (1989) Infection of human peripheral blood mononuclear cells with a temperature-sensitive mutant of measles virus. J Virol 63: 689–695

    PubMed  CAS  Google Scholar 

  • Wechsler SL, Fields BN (1978) Differences between the intracellular polypeptides of measles and subacute sclerosing panencephalitis virus. Nature 272: 458–460

    Article  PubMed  CAS  Google Scholar 

  • Wild TF, Malvoisin E, Buckland R (1991) Measles virus: both the hemagglutinin and fusion glycoproteins are required for fusion. J Gen Virol 72: 439–442

    Article  PubMed  CAS  Google Scholar 

  • Wong Te, Hirano A (1987) Structure and function of bicistronic RNA encoding the phosphoprotein and matrix protein of measles virus. J Virol 61: 584–589

    PubMed  CAS  Google Scholar 

  • Yeo RP, Afzal MA, Forsey T, Rima BK (1993) Identification of a new mumps virus lineage by nucleotide sequence analysis of the SH gene of ten different strains. Arch Virol 128: 371–377

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa Y, Tsuruoka H, Matsumoto M, Haga T, Shioda T, Shibuta H, Sato TA, Yamanouchi K (1990) Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis: II nucleotide sequence of cDNA corresponding to the P plus M dicistronic mRNA. Virus Genes 4: 151–162

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Biology and Biochemistry, Medical Biology Centre, The Queen’s University of Belfast, 97, Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK

    B. K. Rima & J. A. P. Earle

  2. Institute of Virology, University of Würzburg, Versbacher Strasse 7, 97078, Würzburg, Germany

    K. Baczko

  3. Division of Viral and Rickettsial Diseases, Measles Virus Section CID, REVG Mailstop G17, 16000 Clifton Road, Atlanta, GA, 30333, USA

    P. A. Rota & W. J. Bellini

Authors
  1. B. K. Rima
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  2. J. A. P. Earle
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  3. K. Baczko
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  4. P. A. Rota
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  5. W. J. Bellini
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Editor information

Editors and Affiliations

  1. Institut für Virologie und Immunbiologie der Universität Würzburg, Versbacher Strasse 7, 97078, Würzburg, Germany

    Volker ter Meulen

  2. Institut für Molekularbiologie I, Universität Zürich, Hönggerberg, 8093, Zürich, Switzerland

    Martin A. Billeter

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© 1995 Springer-Verlag Berlin Heidelberg

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Rima, B.K., Earle, J.A.P., Baczko, K., Rota, P.A., Bellini, W.J. (1995). Measles Virus Strain Variations. In: ter Meulen, V., Billeter, M.A. (eds) Measles Virus. Current Topics in Microbiology and Immunology, vol 191. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78621-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-78621-1_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78623-5

  • Online ISBN: 978-3-642-78621-1

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