Expression of Immediate Early Transcription Factors in Human Renal Cell Tumors

  • T. Strohmeyer
  • W. Levin
  • M. Press
  • P. Effert
  • D. Slamon
Conference paper


Initiation and progression of malignant growth is a multistep process. Various genes are likely to play potential roles in this process, of which cellular oncogenes and suppressor genes have recently been the focus of investigation. Cellular oncogenes are involved in the regulation of normal growth and/or differentiation and in the signal transduction pathway or in the transcriptional regulation of gene expression of diverse cellular genes. Transcription factors, representing proteins that regulate gene expression by binding to specific regulatory DNA sequences, have been implicated in oncogenesis since structural or functional changes in these factors may result in an altered expression of multiple genes, subsequently leading to changes in both growth properties and differentiation state of affected cells. The transcription factors c-fos, c-jun, and early response gene (EGR-1) are members of a class of proto-oncogenes known as immediate early genes. Genes belonging to this class are characterized by their mRNA levels being strongly induced by serum stimulation: within 20 min after serum stimulation of serum-starved 3T3 cells the mRNA levels of these genes are induced 40- to 50-fold. To date, little is known about the expression of these genes in primary human renal cell carcinomas [1].


Renal Cell Carcinoma Proximal Tubule Serum Stimulation Normal Renal Tissue Normal Kidney Tissue 
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  1. 1.
    Herschman HR (1991) Primaey response genes induces by growth factors and tumor promoters. Annu Rev Biochem 60: 281–319PubMedCrossRefGoogle Scholar
  2. 2.
    Stohmeyery T, Ackermann R (1991) Classic and modern prognostic indicators in renal carcinoma. Urol Int 47:203–212CrossRefGoogle Scholar
  3. 3.
    Sambrook J, Frirsch EF, Maniatis T (1989) Molecular Cloning, a laboratory manual, 2nd edn. CSH Laboratory Press, Cold Spring Harbor, chaps 6 and 7Google Scholar
  4. 4.
    Vogt PK, Bos TJ (1990) Oncogenes and transcripition factors. Adv Cancer Res 55:1–35PubMedCrossRefGoogle Scholar
  5. 5.
    Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (1989) Jun-B inhibits and c-fos stiulates the transforming and trans-activating activities of c-jun. Cell 59:987–997PubMedCrossRefGoogle Scholar
  6. 6.
    Sukhatme VP, Kartha S, Tonack FG, Taub R, Hoover RG, Tsai-Morris C-H (1987) A novel early Growth response gene rapidly induced by fibroblasts, epithelial cell and lymphocyte mitohenes. Oncogene Res 1: 343–355PubMedGoogle Scholar
  7. 7.
    Cao X, Koski RA, Gashler A, McKiernan M, Morris CF, Gaffney R, Hay RV, Sukhateme VP (1990) Identication and Characterization of the EGR-1 gene product, a DNA-bibding zinc finger protein induced by differention and growth signals. Mol Cell Biol 10: 1931–1939PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • T. Strohmeyer
    • 1
    • 2
  • W. Levin
    • 1
  • M. Press
    • 3
  • P. Effert
    • 4
  • D. Slamon
    • 1
  1. 1.Division of Hematology-Oncology, Department of Medicine and the Jonsson Comprehensive Cancer CenterU.C.L.A. School of MedicineLos AngelesUSA
  2. 2.Abteilung für OnkologieSchering AGBerlinGermany
  3. 3.Department of PathologyU.S.C. Medical CenterLos AngelesUSA
  4. 4.Urologische UniversitätsklinikRWTH AachenAachenGermany

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