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Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren’s Disease

  • H. Notbohm
  • S. Mosler
  • J. Hoch
Conference paper

Abstract

Dupuytren’s disease (DD) is a spontaneously occurring tissue rearrangement with a number of biochemical and cellular variations compared to normal fibroblast activity (McFarlaine 1983; Gabbiani and Majno 1972). Fibroblasts are influenced by a number of environmental factors, e.g., cytokines, drugs, or biomechanical stress, which modulate gene expression and therefore the rate of collagen production and extracellular matrix formation. The extracellular matrix of connective tissue is basically constructed of collagen fibrils and various noncollagenous extracellular matrix proteins (Piez 1984). Specific collagen types and proteoglycans modulate the biomechanical character of tissues including skin, bone, cornea, or palmar aponeurosis (Romanic et al. 1991; Birk et al. 1990; Scott 1988; Lapiere et al. 1977). In pathological situations such as fibrosis, the pattern of collagen expression is changed (Bailey et al. 1977).

Keywords

Collagen Type Carpal Tunnel Syndrome Collagen Fibril Osteogenesis Imperfecta Fibril Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Batge B, Notbohm H, Diebold J, Lehmann H, Bodo M, Deutzmann R, Muller PK (1990) A critical crosslink region in human bone derived collagen type I. Eur J Biochem 192: 153–159PubMedCrossRefGoogle Scholar
  2. Bailey AJ, Sims TJ, Gabbiani G, Bazin S, Le Lous M (1977) Collagen of Dupuytren’s disease. Clinical Sci Molec Med 53: 499–502Google Scholar
  3. Birk D, Fitch JM, Babiarz JP, Doanne KJ, Linsenmayer TF (1990) Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter. J Cell Sci 95: 649–657PubMedGoogle Scholar
  4. Brenner RE, Vetter U, Nerlich A, Worsdorfer O, Teller WM, Muller PK (1989)Google Scholar
  5. Biochemical analysis of callus tissue in osteogenesis imperfecta type IV. J Clin Invest 20:8–14Google Scholar
  6. Brokaw JL, Doillon CJ, Hahn R, Birk DE, Berg RA, Silver FH (1985) Turbimetric and morphological studies of type I collagen fibre self assembly anf the influence of fibronectin. Int J Biol Macromol 7: 135–140CrossRefGoogle Scholar
  7. Gabiani G, Majno G (1972) Dupuytren’s contracture: fibroblast contraction? An ultrastructural study. Am J Pathol 66: 131–146Google Scholar
  8. Hueston JT (1990) Cell-controlling factors in Dupuytren’s contracture. Ann Chir Main Memb Super 9 (2): 135–137PubMedCrossRefGoogle Scholar
  9. Hunter JAA, Ogdnon C (1975) Dupuytren’s contracture II: scanning electron microscopic observations. Br J Plastic Surg 28: 19–25Google Scholar
  10. Laemli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685CrossRefGoogle Scholar
  11. Lapiere CM, Nusgens B, Pierard GE (1977) Interaction between collagen type I and III in conditioning bundles organisation. Connective Tiss Res 5: 21–29CrossRefGoogle Scholar
  12. Menzel EJ (1984) Fibronectin in der Dupuytren’schen Kontraktur. Handchirurgie 16: 164–167Google Scholar
  13. Miller EJ, Rhodes RK (1982) Preparation and characterisation of the different types of collagen. Meth Enzymol 82: 33–64PubMedCrossRefGoogle Scholar
  14. Notbohm H, Mosler S, Bodo M, Lehmann HW, Muller PK (1992) Comperative study on the thermostability of collagen I of skin and bone: Influence of posttranslational hydroxylation of prolyl and lysyl residues. J Protein Chem 11: 635–643Google Scholar
  15. Piez K (1984) Molecular and aggregate structures of the collagens. In: Piez KA, Redy AH (eds) Extracellular matrix biochemistry Elsevier, New York, pp 1–13Google Scholar
  16. Romanic AM, Adachi E, Kadler KE, Hojima Y, Prockop DJ (1991) Copolymerisation. of pNcollagen III and collagen I-pNcollagen -III. J Biol Chem 266: 12703–12709PubMedGoogle Scholar
  17. Scott JE (1988) Proteoglycan-fibrillar collagen interactions. Biochem J 252: 313–323PubMedGoogle Scholar
  18. Tomasek JJ, Schultz RJU, Haaksma (1987) Extracellular matrix–cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren’s disease. J Bone Joint Surg 69 (9): 1400–1407Google Scholar
  19. Tunn S, Gurr E, Pallasch Delbriick A, Buhr T, Flory J (1985) The distribution of unsulfated and sulfated glycosaminoglycans in Palmar Fascia from patients with Dupuytren’s disease and healthy subjects. J Clin Chem Clin Biochem 23: 77–87PubMedGoogle Scholar
  20. Williams BR, Gelman RA, Poppke DC, Piez KAJ (1978) Collagen fibril formation. Biol Chem 253: 6578–6585Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • H. Notbohm
  • S. Mosler
  • J. Hoch

There are no affiliations available

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