Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren’s Disease
Dupuytren’s disease (DD) is a spontaneously occurring tissue rearrangement with a number of biochemical and cellular variations compared to normal fibroblast activity (McFarlaine 1983; Gabbiani and Majno 1972). Fibroblasts are influenced by a number of environmental factors, e.g., cytokines, drugs, or biomechanical stress, which modulate gene expression and therefore the rate of collagen production and extracellular matrix formation. The extracellular matrix of connective tissue is basically constructed of collagen fibrils and various noncollagenous extracellular matrix proteins (Piez 1984). Specific collagen types and proteoglycans modulate the biomechanical character of tissues including skin, bone, cornea, or palmar aponeurosis (Romanic et al. 1991; Birk et al. 1990; Scott 1988; Lapiere et al. 1977). In pathological situations such as fibrosis, the pattern of collagen expression is changed (Bailey et al. 1977).
KeywordsCollagen Type Carpal Tunnel Syndrome Collagen Fibril Osteogenesis Imperfecta Fibril Formation
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- Bailey AJ, Sims TJ, Gabbiani G, Bazin S, Le Lous M (1977) Collagen of Dupuytren’s disease. Clinical Sci Molec Med 53: 499–502Google Scholar
- Brenner RE, Vetter U, Nerlich A, Worsdorfer O, Teller WM, Muller PK (1989)Google Scholar
- Biochemical analysis of callus tissue in osteogenesis imperfecta type IV. J Clin Invest 20:8–14Google Scholar
- Gabiani G, Majno G (1972) Dupuytren’s contracture: fibroblast contraction? An ultrastructural study. Am J Pathol 66: 131–146Google Scholar
- Hunter JAA, Ogdnon C (1975) Dupuytren’s contracture II: scanning electron microscopic observations. Br J Plastic Surg 28: 19–25Google Scholar
- Menzel EJ (1984) Fibronectin in der Dupuytren’schen Kontraktur. Handchirurgie 16: 164–167Google Scholar
- Notbohm H, Mosler S, Bodo M, Lehmann HW, Muller PK (1992) Comperative study on the thermostability of collagen I of skin and bone: Influence of posttranslational hydroxylation of prolyl and lysyl residues. J Protein Chem 11: 635–643Google Scholar
- Piez K (1984) Molecular and aggregate structures of the collagens. In: Piez KA, Redy AH (eds) Extracellular matrix biochemistry Elsevier, New York, pp 1–13Google Scholar
- Tomasek JJ, Schultz RJU, Haaksma (1987) Extracellular matrix–cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren’s disease. J Bone Joint Surg 69 (9): 1400–1407Google Scholar
- Williams BR, Gelman RA, Poppke DC, Piez KAJ (1978) Collagen fibril formation. Biol Chem 253: 6578–6585Google Scholar