Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren’s Disease
Dupuytren’s disease (DD) is a spontaneously occurring tissue rearrangement with a number of biochemical and cellular variations compared to normal fibroblast activity (McFarlaine 1983; Gabbiani and Majno 1972). Fibroblasts are influenced by a number of environmental factors, e.g., cytokines, drugs, or biomechanical stress, which modulate gene expression and therefore the rate of collagen production and extracellular matrix formation. The extracellular matrix of connective tissue is basically constructed of collagen fibrils and various noncollagenous extracellular matrix proteins (Piez 1984). Specific collagen types and proteoglycans modulate the biomechanical character of tissues including skin, bone, cornea, or palmar aponeurosis (Romanic et al. 1991; Birk et al. 1990; Scott 1988; Lapiere et al. 1977). In pathological situations such as fibrosis, the pattern of collagen expression is changed (Bailey et al. 1977).
KeywordsQuartz Sedimentation Electrophoresis Proline Lysine
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