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Pharmacological and Binding Evidence for Opioid Receptors on Vertebrate and Invertebrate Blood Cells

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Neuropeptides and Immunoregulation

Abstract

Current evidence indicates that opioid peptides, whose roles in the nervous system are well established, affect immunoactive cells (Smith and Blalock 1981; for review see Blalock 1989). The significance of this phenomenon is highlighted by the discovery that it applies to invertebrates as well as vertebrates (Leung and Stefano 1987; Stefano 1982, 1989). A search for stereoselective mechanisms mediating these neuropeptide activities has been under way for some time. Its results, though still incomplete, seem to indicate that in both groups of animals the complexity of ligand-receptor binding is greater than anticipated. The existing evidence for these parallels presented in this chapter, and in that by Janković and Marić, is based on pharmacological data as well as binding studies.

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Authors and Affiliations

  1. Multidisciplinary Center for the Study of Aging, Old Westbury Neuroscience Research Institute, State University of New York, College at Old Westbury, Old Westbury, NY, 11568-0210, USA

    G. B. Stefano

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  1. G. B. Stefano
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Editor information

Editors and Affiliations

  1. Dept. of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461-1736, Bronx, NY, USA

    Berta Scharrer

  2. Dept. of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 77550, Galveston, TX, USA

    Eric M. Smith

  3. Neuroscience Institute, State University of New York, College at Old Westbury, 11568, Old Westbury, NY, USA

    George B. Stefano

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© 1994 Springer-Verlag Berlin Heidelberg

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Stefano, G.B. (1994). Pharmacological and Binding Evidence for Opioid Receptors on Vertebrate and Invertebrate Blood Cells. In: Scharrer, B., Smith, E.M., Stefano, G.B. (eds) Neuropeptides and Immunoregulation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78480-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-78480-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78482-8

  • Online ISBN: 978-3-642-78480-4

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