Brain Gene Expression in Development and After Injury
The development of any organ or tissue involves the organized generation, migration, differentiation, and interaction of various cell types. The complexity of functionally as well as molecularly defined cell types, both neurons and glia, in the adult nervous system is far greater than in other organs. As well as complex patterns of differentiation, brain development involves especially complex temporal and spatial patterns of cell migration, followed by the establishment and maintenance of complex patterns of synaptic connections between the axon of each neuron in a circuit and the dendrites or cell body of the next. This “hard wiring,” involving trillions of synapses, is the substrate for the constantly fluctuating patterns of synaptic activity that characterize a functioning nervous system. Owing to the length and complexity of neuronal processes, the cell body is a very small part of the neuron’s total volume, and proteins, mostly synthesized in the cell body, must be transported across considerable distances to their sites of utilization, e.g., to a synapse at the distal end of the axon (Fig. 1). Consequently, the generation and maintenance of a functional nervous system must involve the precisely regulated synthesis, transport, utilization, and degradation of a great many different gene products. The advent of recombinant DNA technology has given us the tools to identify some of these gene products and to investigate their synthesis, regulation, and function.
KeywordsNerve Growth Factor Purkinje Cell Glutamic Acid Decarboxylase Purkinje Cell Layer External Granular Layer
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- 2.Border BG, Lin S-C, Griffin WST, Pardue S, Morrison-Bogorad M (1993) Alterations in actin-binding β-thymosin levels accompany neuronal differentiation and migration in rat cerebellum. J Neurochem (in press)Google Scholar
- 17.Gage F, Christen Y (1992): Gene transfer and therapy in the nervous system. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 22.Joho RH (1992) Toward a molecular understanding of voltagegated potassium channels. J Cardiovasc Electrophysiol 3: 589–601Google Scholar
- 23.Kaplan BB, Finch CE (1982) The sequence complexity of brain ribonucleic acids. In: Brown IR (Ed) Molecular Approaches to neurobiology. Academic, New York, pp 71–98Google Scholar
- 30.Loughlin SE, Fallon JH (1993) Neurotrophic factors. Academic Press, San DiegoGoogle Scholar
- 37.Morrison-Bogorad M, Groshan K, Pardue S, Border B, Miller EK, Raese JD (1991) Differential expression of members of the heat shock gene family in brain of adult and aged rats. In: Iqbal K, McLachlan DRC, Winblad B, Wisniewski HM (eds) Alzheimer’s disease: basic mechanisms, diagnosis and therapeutic strategies. Wiley, Chichester, pp 243–252Google Scholar
- 58.Willcutts MD, Griffin WST, Morrison-Bogorad M (1989) Analysis of glutamic acid decarboxylase mRNA levels during cerebellar development in rat. Neurosci Res Comm 6: 57–65Google Scholar