Human Types I and 2 T Helper Subsets: Functional Properties, Role in Disease and Regulation of Development

  • S. Romagnani
Conference paper

Abstract

In recent years it has become clear that the type of an antigen-specific immune response is determined by the selective or preferential activation of CD4+ T cell subsets secreting defined patterns of cytokines that lead to strikingly different T cell functions. Two very distinct cytokine secretion patterns were initially defined among a panel of mouse CD4+ T cell clones (Mosmann et al. 1986). Thelper type 1 (TH1), but not T helper type 2 (TH2), cells produce interleukin (IL)-2, interferon-γ (IFN-γ) and lymphotoxin (LT), whereas TH2, but not TH1, cells express IL-4, IL-5, IL-6 and IL-10. Other cytokines are produced by both T cell subpopulations (Mosmann et al. 1986; Mosmann and Moore 1991). More recent data on the cytokine secretion patterns of T cell clones and normal T cells have revealed the existence of other phenotypes. Among mouse clones, a pattern of IL-2, IL-4, IL-5 and IFN-γ (TH0) has been described (Street et al. 1990), and in some cases these clones have been shown to produce all cytokines tested, including IL-3, IL-10 and granulocyte-macrophage colony-stimulating factor (GM-CSF; Mosmann and Moore 1991).

Keywords

Nickel Arthritis Hepatitis Influenza Tuberculosis 

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© Springer-Verlag Berlin Heidelberg 1994

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  • S. Romagnani

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