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Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity pp 511–524Cite as

Challenges and Directions for Future Research

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 112))

Abstract

It is clear from material reviewed in the preceding chapters that application of the tools of molecular biology to enzyme reactions catalyzing conjugating and deconjugating enzymes has greatly advanced understanding of the expression and regulation of these important drug-metabolizing systems in a variety of tissues. In addition to better understanding the biology of transferases involved in conjugation of biotic and xenobiotic metabolites, it is clear that various hydrolases such as β-glucuronidase, aryl-sulfatase, amidases, and carboxylesterases have critical functions in the net formation and biological activity of many drug and toxic chemical conjugates. Molecular biological approaches being used to define the genetic regulation and tissue distribution of hydrolases involved in processing chemical conjugates are reviewed in several chapters of this volume, since their role in regulating net conjugate production in intact cells is beginning to be recognized.

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  1. F. C. Kauffman
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  1. Laboratory for Cellular and Biochemical Toxicology College of Pharmacy, Rutgers University, Kilmer Campus 41 Gordon Road, Piscataway, NJ, 08854, USA

    Frederick C. Kauffman Ph.D. (Director) (Director)

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Kauffman, F.C. (1994). Challenges and Directions for Future Research. In: Kauffman, F.C. (eds) Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Handbook of Experimental Pharmacology, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78429-3_17

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