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Lipid Apheresis

  • Chapter
Principles and Treatment of Lipoprotein Disorders

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 109))

Abstract

There is ample evidence that diseases resulting from premature atherosclerosis, of which the leading event is myocardial infarction (MI), have great impact on health care in all industrialized countries (Castelli et al. 1990; Cremer and Muche 1990). These illnesses are the most common cause not only of death, but also of early retirement. No doubt this has contributed to the fact that atherosclerosis, together with cancer, is now the primary consideration in experimental, clinical, and preventive medicine. Results of many studies have shown that there are a large number of factors involved in atherogenesis. While disturbances in lipid metabolism (hyperbetalipoproteinemia, hypoalphalipoproteinemia, accumulation of chylomicron and/or very low density lipoprotein, VLDL, remnants), structural abnormalities of lipoproteins (Lp) and family history of MI are the most important risk factors. Hypertension, smoking, elevated blood glucose, and overweight also have an impact on early cardiovascular events. More recently Lp(a), fibrinogen, and the biological modification of lipoproteins have been added to the list of risk factors for atherosclerosis (Seidel et al. 1991; Koenig and Ernst 1992; Smith 1986, 1990; Kienast et al. 1990).

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References

  • Armstrong VW (1987) Die säureinduzierte Präzipitation von Low-DensityLipoproteinen mit Heparin, Grundlagen zum H.E.L.P.-Verfahren. Habilitationsschrift, University of Göttingen

    Google Scholar 

  • Armstrong VW, Schleef J, Thiery J, Muche R, Schuff-Werner P, Eisenhauer T, Seidel D (1989) Effect of H.E.L.P.-LDL apheresis on serum concentrations of human lipoprotein(a): kinetic analysis of the post-treatment return to baseline levels. Eur J Clin Invest 19: 235–240

    Article  PubMed  CAS  Google Scholar 

  • Blankenhorn D, Nessim S, Johnson R, Sanmarco ME, Azen SP et al. (1987) Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 257: 3233–3240

    Article  PubMed  CAS  Google Scholar 

  • Brown BG, Albers JJ, Fisher LD, Schaeffer SM, Lin JT, Kaplan C, Zhao XQ, Bisson BD, Fitzpatrick VF, Dodge HT (1990) Regression of coronary artery disease as a result of intensive lipid lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 323: 1289–1298

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1986) A receptor mediated pathway for cholesterol homeostasis. Science 232: 34–37

    Article  PubMed  CAS  Google Scholar 

  • Buchwald H (1964) Lowering of cholesterol adsorption and blood levels by ileal exclusion. Circulation 29: 713–720

    PubMed  CAS  Google Scholar 

  • Buchwald H, Varco RL, Matts JP, Long JM, Fitch LL, Campbell GS, Pearce MB, Yellin AE, Edmiston WA, Smink RD Jr, Sawin HS Jr, Campos CT, Hansen BJ, Tuna N, Karnegis JN, Sanmarco ME, Amplatz K, Castaneda-Zuniga WR, Hunter DW, Bissett JK, Weber FJ, Stevenson JW, Leon AS, Chalmers TC, the POSCH Group (1990) Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. N Engl J Med 323: 946–955

    Article  PubMed  CAS  Google Scholar 

  • Castelli WP, Wilson PWF, Levy D, Anderson K (1990) Serum lipids and risk of coronary artery disease. Atheroscler Rev 21: 7–19

    Google Scholar 

  • Cremer P, Muche R (1990) Göttinger Risiko-, Inzidenz-und Prävalenzstudie (GRIPS). Empfehlungen zur Prävention der koronaren Herzkrankheit. Ther Umsch 6: 482–491

    Google Scholar 

  • Cremer P, Nagel D, Labrot B, Muche R, Elster H, Mann H, Seidel D (1991) Göttinger Risiko-, Inzidenz-und Prävalenzstudie (GRIPS). Springer, Berlin Heidelberg New York

    Google Scholar 

  • De Gennes J-L, Touraine R, Maunand B, Truffert J, Laudat Ph (1967) Formes homozygotes cutanéo-tendineuses de xanthomatose hypercholestérolémique dans une observation familiale exemplaire. Essai de plasmaphérèse à titre de traitement héroïque. Société Médicale des Hôpitanx de Paris 118: 1377–1402

    Google Scholar 

  • Demant T, Seidel D (1992) Recent developments in low-density lipoprotein apheresis. Curr Opin Lipidol 3: 43–48

    Article  CAS  Google Scholar 

  • Eisenhauer T, Armstrong VW, Wieland H, Fuchs C, Scheler F, Seidel D (1987) Selective removal of low density lipoproteins (LDL) by precipitation at low pH: first clinical application of the H.E.L.P. system. Klin Wochenschr 65: 161–168

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS (1989) Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 1215–1250

    Google Scholar 

  • Gordon BR, Bilheimer DW, Brown DC, Dau PC, Gotto AM, Illingworth DR, Jones PH, Kelsey SF, Leitman SF, Stein EA, Stern TN, Zavoral JH, Zwiener J, for Liposorber Study Group (1991) Multicenter study of the treatment of familial hypercholesterolemia (FH) by LDL-apheresis using the liposorber LA-15 system (abstr). Arterioscler Thromb 11: 1409

    Google Scholar 

  • Greten H, Bleifeld W, Beil FU, Daerr W, Strauer BE, Kleophas W, Gries FA, Schuff-Werner P, Thiery J, Seidel D (1992) LDL-Apherese. Ein therapeutisches Verfahren bei schwerer Hypercholesterinämie. Dtsches Arztebl 89: 48–49

    Google Scholar 

  • Hennerici M, Kleophas W, Gries FA (1991) Regression of carotid plaques during low density lipoprotein cholesterol elimination. Stroke 22: 989–992

    Article  PubMed  CAS  Google Scholar 

  • Keller C (1991) LDL-apheresis: results of long-term treatment and vascular outcome. Atherosclerosis 86: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Kienast J, Berning B, van de Loo J (1990) Fibrinogen als Risikoindikator bei arteriosklerotischen Veränderungen und Koronararterien-Erkrankungen. Diagn Lab 40: 162

    Google Scholar 

  • Kleophas W, Leschke M, Tschöpe D, Martin J, Schauseil S, Schottenfeld Y, Strauer BE, Gries FA (1990) Akute Wirkungen der extrakorporalen LDL-Cholesterinund Fibrinogen-Elimination auf Blutrheologie und Mikrozirkulation. Dtsch Med Wochenschr 115: 7–11

    Article  Google Scholar 

  • Koenig W, Ernst E (1992) The possible role of hemorheology in atherothrombogenesis. Atherosclerosis 94 (3): 93–107

    Article  PubMed  CAS  Google Scholar 

  • Lupien PJ, Moojani S, Award J (1976) A new approach to the management of familial hypercholesterolemia: removal of plasma cholesterol based on the principle of affinity chromatography. Lancet 1: 1261–1265

    Article  PubMed  CAS  Google Scholar 

  • Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, McLanahan SM, Kirkeeide RL, Brand RJ, Gould KL (1990) Can lifestyle changes reverse coronary heart disease? Lancet 336: 129–133

    Article  PubMed  CAS  Google Scholar 

  • Riesen WT, Imhof C, Sturzenegger E, Descoeudres C, Mordasini R, Oetliker OH (1986) Behandlung der Hypercholesterinämie durch extrakorporale Immun-adsorption. Schweiz Med Wochenschr 116: 8

    PubMed  CAS  Google Scholar 

  • Schuff-Werner P, Schütz E, Seyde WC, Eisenhauer T, Janning G, Armstrong VW, Seidel D (1989) Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation ( H.E.L.P. ). Eur J Clin Invest 19: 30–37

    Google Scholar 

  • Schultis H-W, von Bayer H, Neitzel H, Riedel E (1990) Functional characteristics of LDL particles derived from various LDL-apheresis techniques regarding LDLdrug-complex preparation. J Lipid Res 31: 2277–2284

    PubMed  CAS  Google Scholar 

  • Seidel D (1990) The H.E.L.P. system: an efficient and safe method of plasmatherapy in the treatment of severe hypercholesterolemia. Ther Umsch 47: 514–519

    PubMed  CAS  Google Scholar 

  • Seidel D, Wieland H (1982) Ein neues Verfahren zur selektiven Messung and extrakorporalen Elimination von Low-Density-Lipoproteinen. J Clin Chem Clin Biochem 20: 684–685

    Google Scholar 

  • Seidel D, Cremer P, Thiery J (1985) Plasmalipoproteine and Atherosklerose. Intern Welt 5:114–124, 6: 159–165

    Google Scholar 

  • Seidel D, Armstrong VW, Schuff-Werner P, for the H.E.L.P. Study Group (1991) The H.E.L.P.-LDL-apheresis multicenter study, an angiographically assessed trial on the role of LDL-apheresis in the secondary prevention of coronary heart disease: I. Evaluation of safety and cholesterol-lowering effects during the first 12 months. Eur J Clin Invest 21: 375–383

    Article  PubMed  CAS  Google Scholar 

  • Seidel D, Neumeier D, Cremer P, Nagel D (1992) Lipoprotein(a) in internal medicine. In: Stein O, Eisenberg S, Stein Y (eds) Atherosclerosis IX. Proceedings of the 9th International Symposium on Atherosclerosis. R and L Creative Communications, Tel Aviv, pp 127–130

    Google Scholar 

  • Smith EB (1986) Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis. In: Fidge NH, Nestel PJ (eds) Atherosclerosis VI. Elsevier, Amsterdam, pp 459–462

    Google Scholar 

  • Smith EB (1990) Transport, interactions and retention of plasma proteins in the intima: the barrier function of the internal elastic lamina. Eur Heart J 11 Suppl E: 72–81

    Google Scholar 

  • Starzl TE, Bilheimer DW, Bahnson HT, Shaw BW, Hardesty RL, Griffith BP, Iwatsuki S, Zitelli BJ, Gartner JC, Malatack JJ, Urbach AH (1984) Heart—liver transplantation in a patient with familial hypercholesterolemia. Lancet 1: 1382–1383

    Article  PubMed  CAS  Google Scholar 

  • Starzl TE, Chase HP, Ahrens EH, McNamara DJ, Bilheimer DW, Schaefer EF, Rey J, Porter KA, Stein E, Francavilia A, Benson LN (1983) Portocaval shunt in patients with familial hypercholesterolemia. Ann Surg 198: 273–283

    Article  PubMed  CAS  Google Scholar 

  • Stoffel W, Demant T (1981) Selective removal of apolipoprotein B-containing serum lipoproteins from blood plasma. Proc Natl Acad Sci USA 78: 611–615

    Article  PubMed  CAS  Google Scholar 

  • Study Group of the European Atherosclerosis Society (1987) Strategies for the prevention of coronary heart disease: a policy statement of the European Atherosclerosis Society. Eur Heart J 8: 77–88

    Google Scholar 

  • Tatami R, Inoue N, Itoh H, Kishino B, Koga N, Nakashima Y, Nishide T, Okamura K, Saito Y, Teramoto T, Yasugi T, Yamamoto A, Goto Y, for the LARS Investigators (1992) Regression of coronary atherosclerosis by combined LDLapheresis and lipid-lowering drug therapy in patients with familial hypercholesterolemia: a multicenter study. Atherosclerosis 95: 1–13

    CAS  Google Scholar 

  • The Expert Panel (1988) Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults. Arch Intern Med 148: 36–39

    Article  Google Scholar 

  • Thiery J (1988) Maximaltherapie der Hypercholesterinämie bei koronarer Herzkrankheit. Kombination einer Plasmatherapie (H.E.L.P.) mit HMG-CoAReduktasehemmer. Therapiewoche 38: 1–12

    Google Scholar 

  • Thiery J, Armstrong V, Bosch T, Eisenhauer T, Schuff-Werner P, Seidel D (1990a) Maximaltherapy der Hypercholesterinämie bei koronarer Herzerkrankung. Ther Umsch 47 (6): 520–529

    PubMed  CAS  Google Scholar 

  • Thiery J, Walli AK, Janning G, Seidel D (1990b) Low density lipoprotein plasmapheresis with and without lovastatin in the treatment of the homozygous form of familial hypercholesterolemia. Eur J Pediatr 149: 716–721

    Article  PubMed  CAS  Google Scholar 

  • Thompson GR, Lowenthal R, Myant NB (1975) Plasma exchange in the management of homozygous familial hypercholesterolemia. Lancet 1: 1208–1211

    Article  PubMed  CAS  Google Scholar 

  • Würzner R, Schuff-Werner P, Franzke A, Nitze R, Oppermann M, Armstrong VW, Eisenhauer T, Seidel D, Götze 0 (1991) Complement activation and depletion during LDL-apheresis by heparin-induced extracorporeal LDL-precipitation ( H.E.L.P. ). Eur J Clin Invest 21: 288–294

    Google Scholar 

  • Yokoyama S, Hayashi R, Satani M, Yamamoto A (1985) Selective removal of low density lipoprotein by plasmapheresis in familial hypercholesterolemia. Atherosclerosis 5: 613

    CAS  Google Scholar 

Note Added in Proof

  • Schuff-Werner P, Gohlke H, Bartmann U, Corti MC, Dinsenbacher A, Eisenhauer T, Grutzmacher P, Keller C, Kettner U, Kleophas W, Kuster W, Olbricht CJ, Richter WO, Seidel D and the HELP-Study Group (1993) The Help-LDLApheresis Multicenter Study, an angiographically assessed trial on the role of LDL-apheresis in the secondary prevention of coronary heart disease. II. Final evaluation of the effect of regular treatment on LDL-cholesterol plasma concentrations and the course of coronary heart disease. Eur J Clin Invest (in press)

    Google Scholar 

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Authors
  1. D. Seidel
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Editors and Affiliations

  1. Klinisches Institut für Herzinfarktforschung an der Medizinischen Universitätsklinik, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Gotthard Schettler

  2. School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, University of Heidelberg, Bergheimer Straße 58, D-69115, Heidelberg, Germany

    Andreas J. R. Habenicht

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© 1994 Springer-Verlag Berlin Heidelberg

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Seidel, D. (1994). Lipid Apheresis. In: Schettler, G., Habenicht, A.J.R. (eds) Principles and Treatment of Lipoprotein Disorders. Handbook of Experimental Pharmacology, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78426-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-78426-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78428-6

  • Online ISBN: 978-3-642-78426-2

  • eBook Packages: Springer Book Archive

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