The Multicenter Hemophilia Study: A Collaborative Natural History Project

  • J. J. Goedert


The Multicenter Hemophilia Cohort Study (MHCS) is a multidisciplinary prospective cohort study of the natural history of persons with hemophilia and related coagulation disorders. Our primary objectives at the U. S. National Cancer Institute are to characterize and quantify risk factors for human immunodeficiency virus (HIV) infection, hepatitis B and C (HBV and HCV) infections, acquired immunodeficiency syndrome (AIDS), cancer, and other diseases. We also encourage and support others in studying issues relevant to AIDS and other diseases, sexual behavior and education, immunology, and general aspects of coagulation, hemophilia, and its complications.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eyster, M. E., Goedert, J. J., Poon, M. C., and Preble, O. T.: Acid-labile alpha interferon: a possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia. New England Journal of Medicine 309:583–586, 1983.PubMedCrossRefGoogle Scholar
  2. 2.
    Goedert, J. J., Sarngadharan, M. G., Eyster, M. E., Weiss, S. H., Bodner, A. J., Gallo, R. C., and Blattner, W. A.: Antibodies reactive with human T-cell leukemia viruses (HTLV-III) in the serum of hemophiliacs receiving Factor VIII concentrate. Blood 65:492–495, 1985.PubMedGoogle Scholar
  3. 3.
    Goedert, J. J., Kessler, C. M., Aledort, L. M., Biggar, R. J., Andes, W. A., White, G. C. II, Drammond, J. E., Vaidya, K., Mann, D. L., Eyster, M. E., Ragni, M. V., Lederman, M. M., Cohen, A. R., Bray, G. L., Rosenberg, P. S., Friedman, R. M., Hilgartner, M. W., Blattner, W. A., Kroner, B., and Gail, M. H.: A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. New England Journal of Medicine 321:1141–1148, 1989.PubMedCrossRefGoogle Scholar
  4. 4.
    Koch, K. L., Shankey, V., Weinstein, G. S., Dye, R. E., Abt, A. B., Current, W. L., and Eyster, M. E.: Cryptosporidiosis in a patient with hemophilia, common variable hypogammaglobulinemia, and the acquired immunodeficiency syndrome. Annals of Internal Medicine 99:337–340, 1983.PubMedGoogle Scholar
  5. 5.
    Rabkin, C. S. Hilgartner, N. W., Hedberg, K. W., Aledort, L. M., Hatzakis, A., Eichinger, S., Eyster, M. E., White, G. C. II, Kessler, C. M., Lederman, M. M., deMoerloose, P., Bray, G. L., Cohen, A. R., Andes, W. A., Manco-Johnson, M., Schramm, W., Kroner, B., Blattner, W. A., and Goedert, J. J.: Incidence of lymphomas and other cancers in HIV-infected and HIV-uninfected patients with hemophilia. Journal of the American Medical Association 267:1090–1094, 1992.PubMedCrossRefGoogle Scholar
  6. 6.
    Eyster, M. E., Rabkin, C. S., Hilgartner, M. W., Aledort, L. M., Ragni, M. V., Sprandio, J., White, G. C., Eichinger, S., deMoerloose, P., Andes, W. A., Cohen, A. R., Manco-Johnson, M., Bray, G. L., Schramm, W. Hatzakis, A., Lederman, M. M., Kessler, C. M., and Goedert, J. J.: Human immunodeficiency virus related conditions in children and adults with hemophilia: rates, relationship to CD4 counts and predictive value. Blood 81:828–834, 1993.PubMedGoogle Scholar
  7. 7.
    Eyster, M. E., Ballard, J. O., Gail, M. H., Drammond, J. E., and Goedert, J. J.: Predictiva markers for the acquired immunodeficiency syndrome (AIDS) in hemophiliacs: Persistence of p24 antigen and low T4 cell count. Annals of Internal Medicine 110:963–969, 1989.PubMedGoogle Scholar
  8. 8.
    Goedert, J. J., Eyster, M. E., Biggar, R. J., and Blattner, W. A.: Heterosexual transmission of human immunodeficiency virus: Association with severe depletion of T-helper lymphocytes in men with hemophilia. AIDS Research and Human Retroviruses 3:355–361, 1987.PubMedCrossRefGoogle Scholar
  9. 9.
    Goedert, J. J., Eyster, M. E., Ragni, M. V., Gail, M. H.: Rate of heterosexual HIV transmission and associated risk with HIV-antigen. Fourth International Conference on AIDS, Swedish Ministry of Health and Social Affairs and World Health Association, Stockholm, 1988, Abstract 4019, Book 1, p. 264.Google Scholar
  10. 10.
    Dublin, S., Rosenberg, P. S., and Goedert, J. J.: Patterns and predictors of high-risk sexual behavior in female sexual partners of HIV-infected men with hemophilia. AIDS 6:475–482, 1992.PubMedCrossRefGoogle Scholar
  11. 11.
    Eyster, M. E., Alter, H. J., Aledort, L. M., Quan, S., Hatzakis, A., and Goedert, J. J.: Heterosexual co-transmission of hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Annals of Internal Medicine 115:764–768, 1991.PubMedGoogle Scholar
  12. 12.
    Bray, G. L., Kroner, B. S., Arkin, S., Aledort, L. M., Hilgartner, M. W, Eyster, M. E., Ragni, M. V., and Goedert, J. J.: Loss of high-responder inhibitors in patients with severe hemophilia A and human immunodeficiency virus type 1 infection: A report from the Multicenter Hemophilia Cohort Study. American Journal of Hematology 42:375–379, 1993.PubMedCrossRefGoogle Scholar
  13. 13.
    Rosenberg, P. S., Gail, M. H., Schrager, L. K., Vermund, S. H., Craagh-Kirk, T., Andrews, E. B., Winkelstein, W. Jr., Marmor, M., DesJarlais, D. C., Biggar, R. J., and Goedert, J. J.: National AIDS incidence trends and the extent of zidovudine therapy in selected demographic and transmission groups. Journal of Acquired Immune Deficiency Syndromes 4:392–401, 1991.PubMedGoogle Scholar
  14. 14.
    Eyster, M. E., Diamondstone, L. S., Lien, J. M., Ehmann, C., Quan, S., and Goedert, J. J.: Natural history of hepatitis C virus infection in multitransfused hemophiliacs: Effect of coinfection with human immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes 6:602–610, 1993.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. J. Goedert

There are no affiliations available

Personalised recommendations