Clinical Trials Adults with Acute Myelogenous Leukemia: Experience of the Eastern Cooperative Oncology Group

  • J. M. Rowe
  • J. W. Andersen
  • P. A. Cassileth
  • M. M. Oken
  • J. M. Bennett
  • P. H. Wiernik
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Over the past 15 years, the Eastern Cooperative Oncology Group has conducted a series of studies in patients with AML, sequentially escalating the post-remission therapy. While there has not been a major improvement in the number of adult patients who can achieve a complete remission, intensifying the post remission therapy appears to have led to an improved disease-free survival rate (Fig. 1) and has formed the basis for a major intergroup study prospectively evaluating the role of three different intensive post-remission regimens. This report will focus on de novo AML and, in addition to describing three major ongoing randomized studies, will also discuss the impact that previous ECOG studies have had on the design of current studies for dose intensity in postremission therapy.

Keywords

Placebo Leukemia Oncol Neutropenia Cyclophosphamide 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • J. M. Rowe
    • 1
  • J. W. Andersen
    • 2
  • P. A. Cassileth
    • 3
  • M. M. Oken
    • 4
  • J. M. Bennett
    • 5
  • P. H. Wiernik
    • 6
  1. 1.Hematology UnitUniversity of Rochester Medical CenterRochesterUSA
  2. 2.Dana Farber Cancer InstituteBostonUSA
  3. 3.Sylvester Comprehensive Cancer Center, University of MiamiMiamiUSA
  4. 4.Virginia Piper Cancer InstituteMinneapolisUSA
  5. 5.University of Rochester Cancer CenterRochesterUSA
  6. 6.Albert Einstein Cancer CenterBronxUSA

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