Cranial Irradiation is Essential in the Treatment of Childhood Acute Myelogenous Leukemia: Results of Study AML-BFM-87

  • U. Creutzig
  • J. Ritter
  • G. Schellong
  • AML-BFM Study Group
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

In children with acute myelogenous leukemia (AML) the value of prophylactic cranial irradiation still remains controversial. In the first two German pediatric AML studies BFM-78 and -83 [1,2] cranial irradiation was included, whereas in study AML-BFM-87 patients were initially randomized for irradiation to determine the therapeutic value of irradiation for preventing CNS relapses. Later in study AML-BFM-87 CNS irradiation was abandoned in patients without CNS involvement to reduce CNS toxicity. However, first analyses suggest cranial irradiation should be included in the therapy of all patients with AML, not only to prevent CNS- but also systemic relapses.

Keywords

Toxicity Leukemia Cyclophosphamide Cytosine Dura 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • U. Creutzig
    • 1
  • J. Ritter
    • 1
  • G. Schellong
    • 1
  • AML-BFM Study Group
    • 1
  1. 1.University Children’s Hospital MünsterGermany

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