Childhood Acute Lymphoblastic Leukemia and Acute Non-Lymphoblastic Leukemia: Differences in Cellular Drug Resistance, with Emphasis on Glucocorticoids — A Pilot Study
The improvement in the prognosis of childhood leukemia has been more impressive in acute lymphoblastic leukemia (ALL) than in acute non-lymphoblastic leukemia (ANLL). Using first-line multi-agent chemotherapy about 70% of all children with ALL can be cured  compared to 40–50% at best in childhood ANLL . This differences might be caused by a relative resistance of the ANLL cells to the applied cytostatic agents. Therefore, we studied whether differences in cellular resistance to 14 drugs could be detected between untreated ALL and ANLL samples. Special attention was given to glucocorticoids (GC). GC are highly effective in childhood ALL, but largely ineffective in ANLL . However, GC might be of benefit to certain ANLL patients, who are difficult to identify clinically.
KeywordsLeukemia Dexamethasone Glucocorticoid Alkaloid Prednisolone
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