Childhood Acute Lymphoblastic Leukemia and Acute Non-Lymphoblastic Leukemia: Differences in Cellular Drug Resistance, with Emphasis on Glucocorticoids — A Pilot Study
The improvement in the prognosis of childhood leukemia has been more impressive in acute lymphoblastic leukemia (ALL) than in acute non-lymphoblastic leukemia (ANLL). Using first-line multi-agent chemotherapy about 70% of all children with ALL can be cured  compared to 40–50% at best in childhood ANLL . This differences might be caused by a relative resistance of the ANLL cells to the applied cytostatic agents. Therefore, we studied whether differences in cellular resistance to 14 drugs could be detected between untreated ALL and ANLL samples. Special attention was given to glucocorticoids (GC). GC are highly effective in childhood ALL, but largely ineffective in ANLL . However, GC might be of benefit to certain ANLL patients, who are difficult to identify clinically.
KeywordsAcute Lymphoblastic Leukemia Glucocorticoid Receptor Acute Leukemia Childhood Acute Lymphoblastic Leukemia Drug Resistance Testing
Unable to display preview. Download preview PDF.
- 1.Rivera GK, Raimondi SC, Hancock ML, Behm FR, Pui C-H, Abromowitch M, Mirro J Jr, Ochs JS, Look TA, Williams DL, Murphy SB, Dahl GV, Kalwinsky DK, Evans WE, Kun LE, Simone JV, Crist WM (1991) Improved outcome in childhood acute lymphoblastic leukaemia with reinforced early treatment and rotational combination chemotherapy. Lancet 337: 61–66PubMedCrossRefGoogle Scholar
- 6.Pieters R, Kaspers GJL, Van Wering ER, Huismans DR, Loonen AH, Hählen K, Veerman AJP (1992) In vitro drug resistance in childhood acute lymphoblastic leukemia in relation to age and immunophenotype. Haematol Blood Transf 34: 309–320Google Scholar
- 14.Crabtree GR, Smith KA, Munck A (1978) Glucocorticoid receptors and sensitivity of isolated human leukemia and lymphoma cells. Cancer Res 38: 4266–4272Google Scholar
- 19.Kaspers GJL, Pieters R, Van Zantwijk CH, De Waal FC, Van Wering ER, Veerman AJP (1992) Sensitivity of childhood acute lymphoblastic leukemia cells to prednisolone and dexamethasone assessed by the MTT assay. Haematol Blood Transf 34: 327–331Google Scholar