Elevated Plasma Neuropeptide Y as a Marker of B Cell Precursor Leukemia in Children
Neuropeptida Y (NPY) was investigated in childhood acute leukemia using a competitive radioimmunoassay, northern Blot and in situ hybridization. Plasma NPY was mainly elevated in children with leukemia with favourable outcome and may be used as a marker of B cell precursor ALL (sensitivity 80%, specificity 100%). NPY mRNA was detected in leukemic bone narrow in CD10+ lymphoblasts.
KeywordsAcute Leukemia Matched Healthy Control Neutral Endopeptidase Childhood Acute Leukemia Autoimmune Mouse
Unable to display preview. Download preview PDF.
- 5.Kogner P, Björk O, Hedborg F, Nordenskjöld A, Nordenskjold M, Söderhäll S, Theodorsson E (1991) Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. Prog Clin Biol Res 336: 351–357Google Scholar
- 11.Lenkei R, Björk O, Öst Å, Biberfeldt P (1991) Expression of CD15 as predictor of relapse in children with acute lymphoblastic leukemia of the pre-B type. Leukemia Res, in pressGoogle Scholar
- 14.Shipp MA, Stefano GB, Switzer SN, Griffin JD, Reinherz EL (1991) CDIO (CALLA)/Neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology migration, and adhesion proteins and is itself regulated by neutrophil activation. Blood 78: 1834–1841PubMedGoogle Scholar