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Elevated Plasma Neuropeptide Y as a Marker of B Cell Precursor Leukemia in Children

  • P. Kogner
  • A. Ericsson
  • G. Barbany
  • H. Persson
  • E. Theodorsson
  • O. Björk
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Neuropeptida Y (NPY) was investigated in childhood acute leukemia using a competitive radioimmunoassay, northern Blot and in situ hybridization. Plasma NPY was mainly elevated in children with leukemia with favourable outcome and may be used as a marker of B cell precursor ALL (sensitivity 80%, specificity 100%). NPY mRNA was detected in leukemic bone narrow in CD10+ lymphoblasts.

Keywords

Acute Leukemia Matched Healthy Control Neutral Endopeptidase Childhood Acute Leukemia Autoimmune Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • P. Kogner
    • 1
    • 2
  • A. Ericsson
    • 3
  • G. Barbany
    • 3
  • H. Persson
    • 3
  • E. Theodorsson
    • 2
  • O. Björk
    • 1
  1. 1.Departments of PediatricsKarolinska InstituteStockholmSweden
  2. 2.Clinical ChemistryKarolinska InstituteStockholmSweden
  3. 3.Karolinska Hospital, Department of Medical Chemistry, Laboratory of Molecular NeorobiologyKarolinska InstituteStockholmSweden

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