Elevated Plasma Neuropeptide Y as a Marker of B Cell Precursor Leukemia in Children

  • P. Kogner
  • A. Ericsson
  • G. Barbany
  • H. Persson
  • E. Theodorsson
  • O. Björk
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Neuropeptida Y (NPY) was investigated in childhood acute leukemia using a competitive radioimmunoassay, northern Blot and in situ hybridization. Plasma NPY was mainly elevated in children with leukemia with favourable outcome and may be used as a marker of B cell precursor ALL (sensitivity 80%, specificity 100%). NPY mRNA was detected in leukemic bone narrow in CD10+ lymphoblasts.

Keywords

Zinc Migration Leukemia Polypeptide Neuroblastoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tatemoto K, Carlquist M, Mutt V (1982) Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296: 659–660PubMedCrossRefGoogle Scholar
  2. 2.
    Larhammar D, Ericsson A, Persson H (1987) Structure and expression of the rat neuropeptide Y gene. Proc Nat Acad Sci USA 84: 2068–2072PubMedCrossRefGoogle Scholar
  3. 3.
    Allen JM, Bloom SR (1986) Neuropeptide Y: a putative neurotransmitter. Neurochem Int 8: 1–8PubMedCrossRefGoogle Scholar
  4. 4.
    Adrian TE, Allen JM, Terenghi G et al. (1983) Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas. Lancet ii: 540–542CrossRefGoogle Scholar
  5. 5.
    Kogner P, Björk O, Hedborg F, Nordenskjöld A, Nordenskjold M, Söderhäll S, Theodorsson E (1991) Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. Prog Clin Biol Res 336: 351–357Google Scholar
  6. 6.
    Kogner P, Björk O, Theodorsson E (1990) Neuropeptide Y as a marker in pediatric neuroblastoma. Pediatr Pathol 10: 207–216PubMedCrossRefGoogle Scholar
  7. 7.
    Kogner P, Theodorsson E, Björk O (1990) Neuropeptide Y in pediatric neural crest tumors: Correlation with malignancy, metastases and clinical outcome. Ann NY Acad Sci 611: 495–496CrossRefGoogle Scholar
  8. 8.
    Ericsson A, Schalling M, Mc Intyre KR et al. (1987) Detection of neuropeptide Y and its mRNA in megakaryocytes: Enhanced levels in certain autoimmune mice. Proc Natl Acad Sci USA 84: 5585–5589PubMedCrossRefGoogle Scholar
  9. 9.
    Ericsson A, Hemsén A, Lundberg JM, Persson H (1991) Detection of neuropeptide Y -like immunoreactivity and messenger RNA in rat platelets: The effect of vinblastine, reserpine and dexamethasone on NPY expression in blood cells. Exp Cell Res 192: 604–611PubMedCrossRefGoogle Scholar
  10. 10.
    Theodorsson-Norheim E, Hemsen A, Lundberg JM (1985) Radioimmunoassay for neuropeptide Y (NPY): Chromatographic characterization of immunoreactivity in plasma and tissue extracts. Scand J Clin Lab Invest 45: 355–365PubMedCrossRefGoogle Scholar
  11. 11.
    Lenkei R, Björk O, Öst Å, Biberfeldt P (1991) Expression of CD15 as predictor of relapse in children with acute lymphoblastic leukemia of the pre-B type. Leukemia Res, in pressGoogle Scholar
  12. 12.
    Sung CP, Arleth AJ, Feuerstein GZ (1991) Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes. Circulation Res 68: 314–318PubMedGoogle Scholar
  13. 13.
    Letarte M, Vera S, Tran R et al. (1988) Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase. J Exp Med 168: 1247–1253PubMedCrossRefGoogle Scholar
  14. 14.
    Shipp MA, Stefano GB, Switzer SN, Griffin JD, Reinherz EL (1991) CDIO (CALLA)/Neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology migration, and adhesion proteins and is itself regulated by neutrophil activation. Blood 78: 1834–1841PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • P. Kogner
    • 1
    • 2
  • A. Ericsson
    • 3
  • G. Barbany
    • 3
  • H. Persson
    • 3
  • E. Theodorsson
    • 2
  • O. Björk
    • 1
  1. 1.Departments of PediatricsKarolinska InstituteStockholmSweden
  2. 2.Clinical ChemistryKarolinska InstituteStockholmSweden
  3. 3.Karolinska Hospital, Department of Medical Chemistry, Laboratory of Molecular NeorobiologyKarolinska InstituteStockholmSweden

Personalised recommendations