Abstract
Donor-derived T cells are responsible for graft-versus-host disease after allogeneic bone marrow transplantation1. Animal studies have demonstrated that when they are eliminated, successful transplantation is possible even across major histocompatibility barriers [2,3]. Clinical data confirmed this finding [4], but unfortunately revealed that the risk of graft rejection is markedly increased after transplantation of T cell-depleted grafts [5–7]. Therefore, it was suggested that T lymphocytes are in some way important for successful stem-cell engraftment [8]. Donor T cells, it was hypothesized, could provide additional immunosuppressive activity by acting against alloreactive host lymphocytes, thereby preventing graft rejection [9,10]. Alternatively, lymphocyte-derived growth factors could be essential for lasting engraftment [11,12].
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References
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© 1994 Springer-Verlag Berlin Heidelberg
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Uharek, L. et al. (1994). Graft Rejection After Allogeneic Bone Marrow Transplantation: The Impact of T Cells, Graft-Versus-Host Reaction and Marrow Cell Number. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J. (eds) Acute Leukemias IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78350-0_124
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DOI: https://doi.org/10.1007/978-3-642-78350-0_124
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