Descriptive Epidemiology of Myelodysplastic Syndromes

  • C. Aul
  • N. Gattermann
  • W. Schneider
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Myelodysplastic syndromes (MDS) are clonal bone marrow disorders, characterized by quantitative and qualitative changes within hematopoietic cell lines. It is now generally accepted that they arise from neoplastic transformation of a multipotent hematopoietic progenitor cell. Findings in conformity with the malignant character of MDS are the frequent excess of blast cells in the bone marrow, the occasional occurrence of Auer rods [1], the defective ‘leukemic’ in vitro growth pattern of granulomonopoietic progenitor cells [2] and the presence of characteristic chromosomal abnormalities [3].

Keywords

Arthritis Lymphoma Leukemia Anemia Folic Acid 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. Aul
    • 1
  • N. Gattermann
    • 1
  • W. Schneider
    • 1
  1. 1.Department of Internal Medicine, Hematology and Oncology DivisionHeinrich Heine UniversityDüsseldorf 2Germany

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