Descriptive Epidemiology of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are clonal bone marrow disorders, characterized by quantitative and qualitative changes within hematopoietic cell lines. It is now generally accepted that they arise from neoplastic transformation of a multipotent hematopoietic progenitor cell. Findings in conformity with the malignant character of MDS are the frequent excess of blast cells in the bone marrow, the occasional occurrence of Auer rods , the defective ‘leukemic’ in vitro growth pattern of granulomonopoietic progenitor cells  and the presence of characteristic chromosomal abnormalities .
KeywordsArthritis Lymphoma Leukemia Anemia Folic Acid
Unable to display preview. Download preview PDF.
- 4.World Health Organization (1977) International classification of diseases: 9th revision. World Health Organization, GenevaGoogle Scholar
- 7.Devesa SS, Silverman DT, Young JL, Pollack ES, Brown CC, Horm JW, Percy CL, Myers MH, McKay FW, Fraumeni JF (1987) Cancer incidence and mortality trends among whites in the United States, 1947–84 J Natl Cancer Inst 79: 701–745Google Scholar