Descriptive Epidemiology of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are clonal bone marrow disorders, characterized by quantitative and qualitative changes within hematopoietic cell lines. It is now generally accepted that they arise from neoplastic transformation of a multipotent hematopoietic progenitor cell. Findings in conformity with the malignant character of MDS are the frequent excess of blast cells in the bone marrow, the occasional occurrence of Auer rods , the defective ‘leukemic’ in vitro growth pattern of granulomonopoietic progenitor cells  and the presence of characteristic chromosomal abnormalities .
KeywordsAcute Myeloid Leukemia Chronic Lymphocytic Leukemia Myelodysplastic Syndrome Hematopoietic Cell Line Bone Marrow Specimen
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