Therapy-Related Acute Promyelocytic Leukemia: A Report on 16 Cases
Therapy related acute myeloid leukemias (tAML), are usually preceded by a preleukemic phase, are associated with rearrangements involving chromosomes 5 and/or 7, often complex, and carry a poor prognosis [1,2]. About 10% of tAML, however, are associated with cytogenetic rearrangements “specific” of de novo AML, ie t(8; 21), balanced translocations involving 11q23, inv(16), or t(15; 17). This subset of tAML is characterized by the absence of preleukemic phase, and better response to chemotherapy [3–5]. Furthermore, in this subset of tAML, topoisomerase II inhibitors (including the epipodophyllotoxins etoposide and teniposide, and anthracyclines and their derivatives) rather than alkylating agents appeared to be causativeagents [6,7]. However, this finding has been mainly established for tAML with translocations involving l1q23 [7–11] and, very few cases of therapy related acute pro myelocytic leukemia (tAPL) have so far been reported . We gathered 16 cases of tAPL from 7 haematological centers in order to analyze the type of prior tumor and of prior therapy in those patients, and the haematological characteristics and therapeutic outcome of tAPL.
KeywordsLymphoma Leukemia Methotrexate Cyclophosphamide Alkaloid
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