Advertisement

Therapy-Related Acute Promyelocytic Leukemia: A Report on 16 Cases

  • L. Detourmignies
  • S. Castaigne
  • A. M. Stoppa
  • J. L. Harousseau
  • A. Sadoun
  • M. Janvier
  • J. L. Demory
  • M. Sanz
  • R. Berger
  • F. Bauters
  • C. Chomienne
  • P. Fenaux
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 36)

Abstract

Therapy related acute myeloid leukemias (tAML), are usually preceded by a preleukemic phase, are associated with rearrangements involving chromosomes 5 and/or 7, often complex, and carry a poor prognosis [1,2]. About 10% of tAML, however, are associated with cytogenetic rearrangements “specific” of de novo AML, ie t(8; 21), balanced translocations involving 11q23, inv(16), or t(15; 17). This subset of tAML is characterized by the absence of preleukemic phase, and better response to chemotherapy [3–5]. Furthermore, in this subset of tAML, topoisomerase II inhibitors (including the epipodophyllotoxins etoposide and teniposide, and anthracyclines and their derivatives) rather than alkylating agents appeared to be causativeagents [6,7]. However, this finding has been mainly established for tAML with translocations involving l1q23 [7–11] and, very few cases of therapy related acute pro myelocytic leukemia (tAPL) have so far been reported [12]. We gathered 16 cases of tAPL from 7 haematological centers in order to analyze the type of prior tumor and of prior therapy in those patients, and the haematological characteristics and therapeutic outcome of tAPL.

Keywords

Acute Myeloid Leukemia Complete Remission Acute Promyelocytic Leukemia Intensive Chemotherapy Vinca Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Pedersen-Bjergaard J, Philip P, Larsen S, Jensen G, Byroting K et al. (1990) Chromosome aberrations and prognostic factors in therapy related myelodysplasia and acute non lymphocytic leukemia. Blood 16: 1083–1091Google Scholar
  2. 2.
    Levine EG, Bloomfield CD (1986) Secondary myelodysplastic syndromes and leukemias. Cancer Genet Cytogenet 4: 1037–1080Google Scholar
  3. 3.
    Kantarjian HM, Keating M, Walters R et al. (1986) The association of specific “favorable” cytogenetic abnormalities with secondary leukemia. Cancer 58: 924–927PubMedCrossRefGoogle Scholar
  4. 4.
    Fenaux P, Lucidarme D, Lai JL, and Bauters F (1989) Favorable cytogenetic abnormalities in secondary leukemia. Cancer 63: 2505–2508PubMedCrossRefGoogle Scholar
  5. 5.
    Fenaux P, Lai JL, Quiqandon I et al. (1991) Therapy related myelodysplastic syndrome and leukemia with no “unfavourable” cytogenetic findings have a good response to intensive chemotherapy: a report on 15 cases. Leukemia and Lymphoma 5: 117–125PubMedCrossRefGoogle Scholar
  6. 6.
    Pederson-Bjergaard J, Daugaard G, Werner Hansen S et al. (1991) Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet ii: 359–62CrossRefGoogle Scholar
  7. 7.
    Pedersen-Bjergaard J. and Philip P. (1991) Two different classes of therapy-related and de-novo acute myeloid leukemia? Cancer Genet. Cytogenet 55: 119–124CrossRefGoogle Scholar
  8. 8.
    De Yore R, Whitlock J, Hainsworth JD, Johnson DH (1989) Therapy-related acute nonlymphocytic leukemia with monocytic features and rearrangement of chromosome 11q. Ann Intern Med 110: 740Google Scholar
  9. 9.
    Pui CH, Behm FG, Raimondi SC et al. (1989) Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med 321: 136PubMedCrossRefGoogle Scholar
  10. 10.
    Albain KS, Le Beau M, Ullirsch R and Schumacher H (1990) implication of prior treatment with drug combinations includings inhibors of topoisomerase II in therapy-related monocytic leukemia with a 9; 11 translocation. Genes, Chromosomes & Cancer 2: 53–58CrossRefGoogle Scholar
  11. 11.
    Rubin CM, Larson RA, Anastasi J et al. (1990) t(3; 21) (q26; q22): A recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. Blood 12: 2594–2598Google Scholar
  12. 12.
    Rosner F, Grunwald H (1990) Chemicals and leukemia, in Leukemia. Henderson E and Lister T editors, Saunders, Philadelphia pp. 271–287Google Scholar
  13. 13.
    Fenaux P, Pollet JP, Vandenbossche-Simon L et al. (1991) Treatment of acute promyelocytic leukemia: a report of 70 cases. Leukemia and Lymphoma 4: 239–248CrossRefGoogle Scholar
  14. 14.
    Fenaux P and Degos L (1991) Treatment of acute promyeIocytic leukemia with all-trans retinoic acid. Leukemia Res 15: 655–657CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • L. Detourmignies
    • 1
  • S. Castaigne
    • 1
  • A. M. Stoppa
    • 1
  • J. L. Harousseau
    • 1
  • A. Sadoun
    • 1
  • M. Janvier
    • 1
  • J. L. Demory
    • 1
  • M. Sanz
    • 1
  • R. Berger
    • 1
  • F. Bauters
    • 1
  • C. Chomienne
    • 1
  • P. Fenaux
    • 1
  1. 1.Departments of Hematology of Lille, Service of Blood DiseasesLaurence DetourmigniesLilleFrance

Personalised recommendations