Significance of Prognostic Factors During an Idarubicin-Containing Regimen in Adult AML
The results of several clinical studies have clearly demonstrated that the anthracycline derivative idarubicin (IDR) exerts a potent activity on both refractory [1, 2] and previously untreated acute leukemia patients [3–6]. Furthermore, in randomized trials, IDR has been shown to be more active in inducing complete remission (CR) than the parent compound daunorubicin (DNR) [3–5]. More recently, it has been suggested that IDR improves the quality of the antineoplastic response, as testified by the high percentage of patients achieving CR after only one induction course; this increase in the speed of cytoreduction may also playa primary role in prolonging disease free survival [DFS]. As a further proof of its antileukemic activity, IDR seems to minimize the influence of several prognostic factors, including age WBC count and FAB type, on the achievement of CR .
KeywordsLeukemia Oncol Cytosine Vincristine Anthracycline
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