Regulated and Constitutive Secretion Studied In Vitro: Control by GTPases at Multiple Levels

  • H.-P. H. Moore
  • L. Carnell
  • R. A. Chavez
  • Y.-T. Chen
  • A. Hwang
  • S. G. Miller
  • Y.-A. Yoon
  • H. Yu
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 1)

Abstract

All eukaryotic cells renew and expand their cell surface by a continuous supply of new plasma membrane components. These are provided by vesicles that bud from the Golgi complex and fuse with the plasma membrane. This process occurs continuously in the absence of any external signal and is thus named “constitutive secretion”. In more differentiated cells, constitutive secretion alone is insufficient to meet other physiological needs. For example, in cells secreting chemical messengers as a means of communication, the special secretory products are often packaged in storage granules that undergo exocytosis only when the cells are appropriately stimulated by external signals. This process is termed “regulated secretion” (for reviews, see Burgess and Kelly 1987; Moore 1987; Miller and Moore 1990a). Many cells possess more than one type of constitutive or regulated secretory pathway. A well-known example is the polarized epithelium with two constitutive pathways for delivery of newly synthesized proteins to either the apical or the basolateral surface (for reviews, see Simons and Fuller 1985; Rodriguez-Boulan and Nelson 1989). The presence of multiple types of vesicles therefore offers the possibility of segregating secretion of different products both spatially and temporally.

Keywords

Surfactant Lipase Adenosine Serotonin Histamine 

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© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • H.-P. H. Moore
  • L. Carnell
  • R. A. Chavez
  • Y.-T. Chen
  • A. Hwang
  • S. G. Miller
  • Y.-A. Yoon
  • H. Yu

There are no affiliations available

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