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Lymphocyte Recirculation and Life Span In Vivo

  • Chapter
Adhesion in Leukocyte Homing and Differentiation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 184))

Abstract

Lymphocytes represent a predominant component of the white blood cells, yet they seem to spend a surprisingly short part of their life history in the blood. In addition, even though they derive their name from being the overwhelmingly dominant cell of lymph, they also seem to spend rather short periods of time in lymphatic vessels (Abernethy and Hay 1992). Nevertheless, many, if not most, lymphocytes continuously move through tissues via these two distinct circulatory systems. This is a highly dynamic process, a feature sometimes overlooked or ignored in studies that require the analysis of cells from dead or fixed tissue at a given point in time. This is not to say that the specific distribution patterns seen in fixed tissues are not relevant or important, but such patterns may not reflect the true physiological interactions and function of a particular cell type in a given tissue, since the time spent may be a significant variable.

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Author information

Authors and Affiliations

  1. Department of Immunology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Canada

    A. J. Young & J. B. Hay

  2. Trauma Research Program, Sunnybrook Health Science Centre, University of Toronto, Toronto, Canada

    A. J. Young & J. B. Hay

  3. Department of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Canada

    J. B. Hay

  4. Basel Institute for Immunology, Basel, Switzerland

    C. R. Mackay

Authors
  1. A. J. Young
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  2. J. B. Hay
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  3. C. R. Mackay
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Dominique Dunon Ph.D. , Charles R. Mackay Ph.D.  & Beat A. Imhof Ph.D. ,  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Young, A.J., Hay, J.B., Mackay, C.R. (1993). Lymphocyte Recirculation and Life Span In Vivo. In: Dunon, D., Mackay, C.R., Imhof, B.A. (eds) Adhesion in Leukocyte Homing and Differentiation. Current Topics in Microbiology and Immunology, vol 184. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78253-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-78253-4_13

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  • Print ISBN: 978-3-642-78255-8

  • Online ISBN: 978-3-642-78253-4

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