Abstract
The met receptor tyrosine kinase is oncogenically activated by a genomic rearrangement that results in the production of a 65 kd protein containing tpr sequences fused directly to the met receptor kinase domain. Tpr was found to be essential for cell transformation mediated by tpr-met. Two leucine zipper motifs have been identified in tpr, one of which is essential for dimerization of tpr-met and cell transformation. From analysis of mutant tpr-met molecules we propose that the leucine zipper region of tpr oncogenically activates the met receptor by promoting constitutive dimerization of the kinase domain. In support of this hypothesis, a kinase negative mutant of tpr-met was found to suppress transformation in a dominant negative fashion.
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© 1993 Springer-Verlag Berlin Heidelberg
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Rodrigues, G.A., Park, M. (1993). Oncogenic Activation of the Met/HGF Receptor Tyrosine Kinase is Promoted by Leucine Zipper Mediated Dimerization. In: Heilmeyer, L.M.G. (eds) Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. NATO ASI Series, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78247-3_9
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DOI: https://doi.org/10.1007/978-3-642-78247-3_9
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