Abstract
The existence of two membrane-bound isoforms of phosphatidylinositol (PtdIns) 4-kinase has been demonstrated in brain (Endemann et al., 1987; Yamakawa and Takenawa, 1988). The type 2 isoform (Mr of 55 kDa) exhibits a high affinity for ATP and a high sensitivity to adenosine inhibition; it does not seem to be organ-specific. The type 3 isoform has little affinity for ATP and adenosine and exists predominantly in brain.
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References
Endemann, G., Dunn, S.N., Cantley, L.C. (1987) Bovine brain contains two types of phosphatidylinositol kinase. Biochemistry 26, 6845–6852.
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© 1993 Springer-Verlag Berlin Heidelberg
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Vereb, G., Schmidt, M., Klix, D., Varsányi, M., Heilmeyer, L.M.G. (1993). Isolation and Characterization of Phosphatidylinositol 4-Kinase Isoenzymes from Bovine Brain. In: Heilmeyer, L.M.G. (eds) Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. NATO ASI Series, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78247-3_21
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DOI: https://doi.org/10.1007/978-3-642-78247-3_21
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