Skip to main content

Polylysine Activates a Splenic Tyrosine Protein Kinase Encoded by the fgr Protooncogene

  • Conference paper
Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

Part of the book series: NATO ASI Series ((ASIH,volume 76))

  • 59 Accesses

Abstract

A tyrosine protein kinase previously isolated from rat spleen, conventionally termed TPK-III, displaying autophosphorylation activity [Brunati and Pinna, 1988], has been purified to homogeneity. The enzyme is immunologically related to the tyrosine kinase encoded by the fgr gene, a member of the src family [Brunati et al., manuscript in preparation].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Brunati, A.M. and Pinna, L.A. (1988). Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen. Eur. J. Biochem. 172, 451–457.

    Article  PubMed  CAS  Google Scholar 

  • Cooper J.A. (1990). The src family of protein-tyrosine kinases. in Peptides and protein phosphorylation (B.E. Kemp ed.) pp. 85–113, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Donella-Deana A., Marin O., Brunati A.M. and Pinna L. (1992). Selective effect of poly(lysine) on the enhancement of the lyn tyrosine protein kinase activity: increased specificity toward src peptides. Eur. J. Biochem. 204, 1159–1163.

    Article  PubMed  CAS  Google Scholar 

  • Matsuda M., Mayer B.J., Fukui Y. and Hanafusa H. (1990). Binding of transforming protein p47gag-crk to a broad range of phosphotyrosine-containing proteins. Science 248, 1537–1539.

    Article  PubMed  CAS  Google Scholar 

  • Nada, S., Okada, M., MacAuley, A., Cooper, J.A. & Nakagawa, H. (1991). Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 351, 69–72.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Donella-Deana, A., Brunati, A.M., Ruzzene, M., Pinna, L.A. (1993). Polylysine Activates a Splenic Tyrosine Protein Kinase Encoded by the fgr Protooncogene. In: Heilmeyer, L.M.G. (eds) Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. NATO ASI Series, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78247-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78247-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78249-7

  • Online ISBN: 978-3-642-78247-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics