Effect of Single-Shot Antibiotic Treatment on Helicobacter pylori in Patients Undergoing Ulcer Operation

  • M. Büchler
  • H. Frieß
  • F. Flock
  • A. Stanescu
  • K. Baczako
  • P. Malfertheiner
Conference paper

Abstract

The significance of Helicobacter pylori in the pathogenesis of duodenal ulcer has broadened the spectrum of drug therapy for ulcers. Preliminary results of treatment with bismuth compounds with or without antibiotics and the recent results of therapy with omeprazole combined with antibiotics indicate that treatment with these drugs is superior to therapy using H2 receptor blockers [2,13,24]. After the eradication of H. pylori, fewer recurrences of duodenal ulcer occur in a period of at least 12 months [2,15,24]. Although proximal gastric vagotomy (PGV) has a lower rate of ulcer relapse in comparison with conservative drug therapy — based on a follow-up period of up to 20 years — surgical treatment continues to play only a subordinate role in the elective treatment of duodenal ulcer [11,12,16,26,29]. In two studies, antral H. pylori infections were described in 94%–100% of patients 6 months-20 years after PGV [10,19]. In contrast. Steer et al. observed a reduction in H. pylori density 3–12 months after PGV [27].

Keywords

Catalase Bismuth Vancomycin Omeprazole Kelly 

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References

  1. 1.
    Bayerdörfer E, Ottenjann R (1988) The role of antibiotics in Campylobacter pylori associated peptic ulcer disease. Scand J Gastroenterol 23 [Suppl 142]: 93–100CrossRefGoogle Scholar
  2. 2.
    Borody T, Noonan S, Cole P, Hyland L, Morgan A, Lenne J et al. (1989) Duodenal ulcer recurrence in patients remaining C.pylori-negSLl’we long term post-eradication. Gastroenterology 96:A52Google Scholar
  3. 3.
    Carrick J, Lee A, Hazell S, Ralston M, Daskalopoulos G (1989) Campylobacter pylori, duodenal ulcer, and gastric metaplasia: possible role of functional heterotopic tissue in ulcerogenesis. Gut 30:790–797PubMedCrossRefGoogle Scholar
  4. 4.
    Fitzgibbons PL, Dooley CP, Cohen H, Applemen MD (1988) Prevalence of gastric metaplasia, inflammation, and Campylobacter pylori in the duodenum of members of a normal population. Am J Clin Pathol 90:711–714PubMedGoogle Scholar
  5. 5.
    Glupczynski Y, Burette A (1991) Acquired resistance to antibiotics: an underestimated cause of failure in the treatment of Helicobacter pylori infection. In: Menge H et al. (eds) Helicobacter pylori Springer, Berlin Heidelberg New YorkGoogle Scholar
  6. 6.
    Glupczynski Y, Burette A, Labbe M, Deprez C, De Reuck M, Deltenre M (1988) Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin. Am J Gastroenetrol 83:365–372Google Scholar
  7. 7.
    Goodwin CS, Marshall BJ, BHncow ED, Wilson DH, Blackbourn S, Philhps M (1988) Prevention of nitroimidazole resistance inCampylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies. J Clin Pathol 41:207–210PubMedCrossRefGoogle Scholar
  8. 8.
    Hirschl AM, Hentschel E, Schütze K, Nemec H, Pötzi R, Gangl A et al. (1988) The efficacy of antimicrobial treatment inCampylobacter pylori-associated gastritis and duodenal ulcer. Scand J Gastroenterol 23 [Suppl 142]: 76–81CrossRefGoogle Scholar
  9. 9.
    Hirschl A, Stanek G, Pötzi R, Rotter M, Wende L (1986) Die Empfindlichkeit von Campylobacter pyloridis gegenüber antimikrobiellen Chemotherapeutika und Ulcustherapeutika. ZAC 2:45–49Google Scholar
  10. 10.
    Hölscher AH, Petkaneschkov G, Bollschweiler E (1989) Effekt der proximal-gastrischen Vagotomie auf die Campylobacter Besiedelung des Magens. Z Gastroenterol 27: A563Google Scholar
  11. 11.
    Jordan PH, Thornby J (1987) Should it be parietal cell vagotomy or selective vagotomy- antrectomy for treatment of duodenal ulcer? Ann Surg 205:572–587PubMedCrossRefGoogle Scholar
  12. 12.
    Koruth NM, Dua KS, Brunt WP, Matheson NA (1990) Comparison of highly selective vagotomy with truncal vagotomy and pyloroplasty: results at 8–15 years. Br J Surg 77 (1): 70–72PubMedCrossRefGoogle Scholar
  13. 13.
    Lamouliate H, Bernard PH, Boulard A, Megraud F (1990) Controlled study of omeprazole- amoxycillin-tinidazol vas ranitidine-amoxiciUin-tinidazol in Helicobacter pylori Associated duodenal ulcer preliminary results. Rev Esp Enferm Dig 78 [Suppl 1]: 101Google Scholar
  14. 14.
    Malfertheiner P, Stanescu A, Bode G, Baczako K, Kühl P, Ditschuneit H (1990) Gastric metaplasia in duodenal mucosa - key factor for H. pylori colonization and duodenal ulcer pathogenesis? In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 292–301CrossRefGoogle Scholar
  15. 15.
    Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ et al. (1988) Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori Lancet ii: 1437–1442CrossRefGoogle Scholar
  16. 16.
    Meisner S, Jorgensen LN, Jensen HE (1988) The Kaplan and Meier and the Nelson estimate for the probability of ulcer recurrence 10 and 15 years after parietal cell vagotomy. Ann Surg 207:1–3PubMedCrossRefGoogle Scholar
  17. 17.
    Morgan D, Kraft WG, Bender M, Pearson A (1988) Nitrofurans in the treatment of gastritis associated with Campylobacter pylori Gastroenterology 95:1178–1184PubMedGoogle Scholar
  18. 18.
    Natelson B, Dubois A, Sodetz FJ (1977) Effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin and hydrogen ion kinetics. Dig Dis Sci 22: 888–897CrossRefGoogle Scholar
  19. 19.
    O’Connor HJ, Dixon HF, Wyatt JI, Axon ATR, Ward DC, Dewar EP et al (1986) Effect of duodenal ulcer surgery and enterogastric reflux on Campylobacter pylori Lancet ii: 1178–1181CrossRefGoogle Scholar
  20. 20.
    Offerhaus GJ, Molyvas EN, Hoedenmaeker PJ (1990) Helicobacter pylori infection of gastric mucin cell metaplasia: the duodenum revisited. J Pathol 162:239–243PubMedCrossRefGoogle Scholar
  21. 21.
    O’Riordan T, Mathai E, Tobin E, McKenna D, Keane C, Sweeney E et al. (1990) Adjuvant antibiotic therapy in duodenal ulcers treated with colloidal bismuth subcitrate. Gut 31:999–1002PubMedCrossRefGoogle Scholar
  22. 22.
    Parrish JA, Rawlings DC (1965) Intestinal mucosa in the Zollinger-Ellison syndrome. Gut 6: 286–289PubMedCrossRefGoogle Scholar
  23. 23.
    Rauws EAJ, Tytgat GNJ (1989) Therapeutic trials of eradication of Campylobacter pylori In: Rauws EAJ, Tytgat GNJ (eds) Campylobacter pylori Den Ouden, Amsterdam, pp 89–100Google Scholar
  24. 24.
    Rauws EA, Tytgat GNJ (1990) Cure of duodenal ulcer associated with eradication of Helicobacter pylori Lancet 335:1233–1235PubMedCrossRefGoogle Scholar
  25. 25.
    Rhodes J (1964) Experimental production of gastric epithehum in the duodenum. Gut 5:454–458PubMedCrossRefGoogle Scholar
  26. 26.
    Soper NJ, Kelly KA, van Heerden JA, Ilstrup DM (1989) Long term clinical results after proximal gastric vagotomy. Surg Gynecol Obstet 169:488–94PubMedGoogle Scholar
  27. 27.
    Steer HW, Hawtin P, Newell DG (1988) The effect of surgical treatment of chronic duodenal ulceration on Campylobacter pylori colonisation of the stomach. Abstract book workshop gastroduodenal pathology and Campylobacter pylori Bordeaux, p 153Google Scholar
  28. 28.
    Tatsuta M, Iishi H, Yamamura H, Yamamoto R, Taniguchi H (1989) Enhancement by tetragastrin of experimental induction of gastric epithelium in the duodenum. Gut 30:311–315PubMedCrossRefGoogle Scholar
  29. 29.
    Vom Holstein CS, Graffner H, Oscarson J (1987) One hundred patients ten years after parietal cell vagotomy. Br J Surg 74:101–103CrossRefGoogle Scholar
  30. 30.
    Whitehead R, Truelove SC, Gear MWL (1972) The histological diagnosis of chronic gastritis in fibreoptic gastroscopy biopsy specimens. J Clin Pathol 25:1–11PubMedCrossRefGoogle Scholar
  31. 31.
    Wyatt JI (1989) The role of Campylobacter pylori in the pathogenesis of peptic ulcer disease. Scand J Gastroenterol 24 [Suppl 157]: 7–11CrossRefGoogle Scholar
  32. 32.
    Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV (1987) Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol 40:841–848PubMedCrossRefGoogle Scholar
  33. 33.
    Wyatt JI, Rathbone BJ, Sóbala GM, Shallcross T, Heatley RV, Axon ATR et al. (1990) Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation. J Clin Pathol 43:981–986PubMedCrossRefGoogle Scholar
  34. 34.
    Xiao SD, Liu WZ, Xia DH, Jiang SJ, Wang RN, Zhang ZH et al. (1990) The efficacy of furazolidone and metronidazole in the treatment of chronic gastritis associated with Helicobacter (Campylobacter) pylori - a randomized double-blind placebo-controlled clinical trial. Hepato- gastroenterology 37 (5): 503–506PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. Büchler
    • 1
  • H. Frieß
    • 1
  • F. Flock
    • 1
  • A. Stanescu
    • 2
  • K. Baczako
    • 3
  • P. Malfertheiner
    • 2
  1. 1.Department of SurgeryUniversity of UlmUlmGermany
  2. 2.Department of GastroenterologyUniversity of UlmUlmGermany
  3. 3.Department of PathologyUniversity of UlmUlmGermany

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