Advertisement

The Role of Helicobacter pylori Gastritis in Ulcerogenesis and Carcinogenesis

  • E. Solcia
  • R. Fiocca
  • L. Villani
  • O. Luinetti
  • A. Gianatti
  • E. Trespi
  • G. Stella
  • M. Cornaggia
  • A. Chiaravalli
  • C. Capella

Abstract

Recent studies suggest that Helicobacter pylori (HP) gastritis is a major risk factor for both peptic ulcer disease [36] and cancer [16, 31, 32]. However, the histologic factors and mechanisms leading from gastritis to ulcer or cancer are poorly known. Gastritis activity and HP-linked surface epithelium lesions have been suggested to play some role in ulcerogenesis [7, 9, 12, 13, 15, 34] while intestinal metaplasia (IM) has long been indicated as a factor in cancerogenesis [6, 21, 22].

Keywords

Peptic Ulcer Duodenal Ulcer Intestinal Metaplasia Chronic Gastritis Nonulcer Dyspepsia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aceti A, Celestino D, Caferro M, Casale V, Citarda F, Conti EM, Grassi A, Grilli A, Pennica A, Sciarretta F, Leri O, Ameglio F, Sebastiani A (1991) Basophil-bound and serum immunoglobulin E directed against Helicobacter pylori in patients with chronic gastritis. Gastroenterology 101:131–137PubMedGoogle Scholar
  2. 2.
    Beauchamp RD, Barnard JA, McCutchen CM, Cherner JA, Coffey RJ (1989) Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest 84:1017–1023PubMedCrossRefGoogle Scholar
  3. 3.
    Bernatowska E, Jose P, Davies H, Stephenson M, Webster D (1989) Interaction ofCampylobacter species with antibody, complement and phagocytes. Gut 30:906–911PubMedCrossRefGoogle Scholar
  4. 4.
    Brandtzaeg P, Halstensen TS, Kett K, Krajci, P, Kvale D, Rognum TO, Scott H, Sollid LM (1989) Immunobiology and immunopathology of human gut mucosa: humoral immunity, and intraepithelial lymphocytes. Gastroenterology 97:1562–1584PubMedGoogle Scholar
  5. 5.
    Correa P, Cuello C, Duque E (1970) Carcinoma and intestinal metaplasia of the stomach in Columbian migrants. J Natl Cancer Inst 44:297–306PubMedGoogle Scholar
  6. 6.
    Correa P, Ruiz B (1989) Campylobacter pylori and gastric cancer. In: Rathbone BJ, Heatley RV (eds) Campylobacter pylori and gastroduodenal disease. Blackwell, Oxford, pp 139–145Google Scholar
  7. 7.
    Crabtree JE, Taylor JD, Wratt JI, Heatley RV, Shallcross TM, Tompkins DS, Rathbone BJ (1991) Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 338:332–335PubMedCrossRefGoogle Scholar
  8. 8.
    Cucala M, Le T, Mugridge K, Parente L, Wallance JL (1991) Inhibitory effects of interleukin-1 on gastric acid secretion are secretagogue-specific. Gastroenterology 100: A49Google Scholar
  9. 9.
    Eidt S, Stolte M (1990) Differences between Helicobacter pylori associated gastritis in patients, with duodenal ulcer, pyloric ulcer, other gastric ulcer, and gastritis without ulcer In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin Heidelberg New York, pp 228–336CrossRefGoogle Scholar
  10. 10.
    Figura N, Guglielmetti P, Rossolini A, Barbieri A, Cusi G, Musmanno RA, Russi M, Quaranta S (1989) Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol. 27:225–226PubMedGoogle Scholar
  11. 11.
    Fiocca R, Solcia E, Santoro B (1991) Duodenal ulcer relapse after eradication oi Helicobacter pylori. Lancet 337:1614PubMedCrossRefGoogle Scholar
  12. 12.
    Fiocca R, Villani L, De Giacomo C, Perego, M, Trespi E, Solcia E (1989) Morphological evidence of Campylobacter pylori pathogenicity in chronic gastritis and peptic ulcer. Acta Gastroenterol Belg 52:324–335Google Scholar
  13. 13.
    Fiocca R, Villani L, Luinetti O, Gianatti A, Perego M, Alvisi C, Turpini F, Solcia E (1992) Helicobacter colonization and histopathologic profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer. A morphologic approach to the study of ulcerogenesis in man. Virchows Arch [A] 420:489–498Google Scholar
  14. 14.
    Fiocca R, Villani L, Tenti P, Cornaggia M, Finzi G, Capella C, Prat M, Bussolati G, Solcia E (1988) Widespread expression of intestinal markers in gastric carcinoma: of light and electronmicroscopic study using BD-5 monoclonal antibody. J Clin Pathol 41:178–187PubMedCrossRefGoogle Scholar
  15. 15.
    Fiocca R, Villani L, Turpini F, Turpini R, Solcia E (1987) High incidence of campylobacter-like organisms in endoscopic biopsies from patients with gastritis, with or without peptic ulcer Digestion 38:234–244PubMedGoogle Scholar
  16. 16.
    Forman D, Sitas F, Newell DG, Stacey AR, Boreham J, Peto R, Campbell TC, Li J, Chen J (1990) Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer 46:608–611PubMedCrossRefGoogle Scholar
  17. 17.
    Gleich GJ, Adolphson CR (1986) The eosinophilic leukocyte: structure and function. Adv Immunol 39:177–253PubMedCrossRefGoogle Scholar
  18. 18.
    Gleich GJ, Schroeter AL, Marcoux JP, Sachs, MI, O’Connell EJ, Kohler PF (1984) Episodic angioedema associated with eosinophilia. N Engl J Med 310:1621–1626PubMedCrossRefGoogle Scholar
  19. 19.
    Gruler H (1988) Necrotaxis and galvanotaxis. Methods Enzymol 162:115–127PubMedCrossRefGoogle Scholar
  20. 20.
    Higuchi K, Matsumoto T, Arakawa T, Kitano A, Nagura H, Kobayashi K (1988) Immunohistochemical localization of prostaglandin E2 (PGE2), in human gastric mucosa. Gastroenterology 94: AI86Google Scholar
  21. 21.
    Ihamaki T, Sipponen P, Varis K, Kekki M, Siurala M (1991) Characteristics of gastric mucosa which procede occurrence of gastric malignancy: Results of long-term follow-up of three family samples. Scand J Gastroenterol 26 [Suppl 186]: 16–23CrossRefGoogle Scholar
  22. 22.
    Johansen A (1981) Gastric carcinoma: a contribution to the pathology and to gastric cancer histogenesis. Bisperbjerg Hospital, CopenhagenGoogle Scholar
  23. 23.
    Karnes WE Jr, Samloff IM Siurala M, Kekki M, Sipponen P, Kim SWR, Walsh JH (1991) Positive serum antibodies and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology 101:167–174PubMedGoogle Scholar
  24. 24.
    Kirchner T, Melber A, Fischbach W, Heilmann KL, Muller-Hermelink HK (1990) Immunohistological patterns of the local immune response in Helicobacter pylori gastritis. In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berhn Heidelberg New York, pp 213–222CrossRefGoogle Scholar
  25. 25.
    Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 26:93–99PubMedCrossRefGoogle Scholar
  26. 26.
    Marshall BJ, Goodwin CS, Warren JR, Murray R, Glincow ED, Blackbourn SJ, Phillips M, Waters TE, Sanderson CR (1988) Prospective double-blind trial of duodenal relapse after eradication of Campylobacter pylori. Lancet 11:1437–1442CrossRefGoogle Scholar
  27. 27.
    McGovern TW, Kephart GM, Gleich GJ, Talley NJ (1989) Eosinophil infiltration and degranulation in Campylobacter pylori gastritis. Klin Wochenschr 67 [Suppl 18]: 46Google Scholar
  28. 28.
    Mirvish S (1986) Effect of Vitamin C and E on N-nitroso compound formation and other theories. J Natl Cancer Inst 58:1842–1850Google Scholar
  29. 29.
    Misiewicz JJ, Tytgat GNJ, Goodwin CS, Price AB, Sipponen P, Strickland RG, Cheli R (1990) The Sydney system: a new classification of gastritis. Working Party reports, world congresses of gastroenterology, Sydney, pp 1–10Google Scholar
  30. 39.
    Mooney C, Keenan J, Munster D, Wilson I, Allardyce R, Bagshaw P, Chapman B, Chadwick V (1991) Neutrophil activation by Helicobacter pylori. Gut 32:853–857PubMedCrossRefGoogle Scholar
  31. 31.
    Nomura A, Stemmermann GN, Chyou PH, Kato I, Perez-Perez GI, Blaser MJ (1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325:1132–1136PubMedCrossRefGoogle Scholar
  32. 32.
    Parsonnet J, Friedman GF, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127–1131PubMedCrossRefGoogle Scholar
  33. 33.
    Parsonnet J, Vandersteen D, Goates J, Sibley RK, Prikikin J, Chang Y (1991) Helicobacter pylori infection in intestinal — and diffuse — type gastric adenocarcinomas. J Natl Cancer Inst 83:640–643PubMedCrossRefGoogle Scholar
  34. 34.
    Rauws EAJ, Langenberg W, Houthoff HJ, Zanen HC, Tytgat GNJ (1988) Campylobacter pyloridis-associsited chronic antral gastritis. Gastroenterology 94:33–40PubMedGoogle Scholar
  35. 35.
    Rauws EAJ, Tytgat GNJ (1990) Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 335:1233–1235PubMedCrossRefGoogle Scholar
  36. 36.
    Sipponen P, Varis K, Fraki O, Korri UM, Seppälä K, Siurala M (1990) Cumulative 10-years risk of symptomatic duodenal and gastric ulcer in patients with or without chronic gastritis. A clinical follow-up of 454 patients. Scand J Gastroenterol 25:966–973PubMedCrossRefGoogle Scholar
  37. 37.
    Solcia E, Capella C, Fiocca R, Cornaggia M, Rindi G, Villani L, Bosi F, Ambrosiani L (1990) Exocrine and endocrine epithelial changes in types A and B chronic gastritis. In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori, gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 245–258CrossRefGoogle Scholar
  38. 38.
    Stacey AR, Hawtin PR, Newell DG (1990) Local immune responses to Helicobacter pylori infections. In: Malfertheiner P, Ditschuneit H (eds) Helicobacter pylori,s gastritis and peptic ulcer. Springer, Berlin Heidelberg New York, pp 162–166CrossRefGoogle Scholar
  39. 39.
    Van der Valk P, Herman CJ (1987) Leukocyte functions. Lab Invest 57:127–137Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • E. Solcia
    • 1
    • 2
  • R. Fiocca
    • 1
  • L. Villani
    • 2
  • O. Luinetti
    • 2
  • A. Gianatti
    • 2
  • E. Trespi
    • 3
  • G. Stella
    • 4
  • M. Cornaggia
    • 5
  • A. Chiaravalli
    • 5
  • C. Capella
    • 5
    • 6
  1. 1.Department of PathologyUniversity of PaviaItaly
  2. 2.Pathology ServiceIRCCS Policlinico San MatteoPaviaItaly
  3. 3.Digestive Physiopathology CenterIRCCS Policlinico San MatteoPaviaItaly
  4. 4.Pathology ServiceGeneral HospitalVogheraItaly
  5. 5.Pathology ServiceGeneral HospitalVareseItaly
  6. 6.Department of PathologyUniversity of PaviaVareseItaly

Personalised recommendations