The Role of Helicobacter pylori Gastritis in Ulcerogenesis and Carcinogenesis

  • E. Solcia
  • R. Fiocca
  • L. Villani
  • O. Luinetti
  • A. Gianatti
  • E. Trespi
  • G. Stella
  • M. Cornaggia
  • A. Chiaravalli
  • C. Capella


Recent studies suggest that Helicobacter pylori (HP) gastritis is a major risk factor for both peptic ulcer disease [36] and cancer [16, 31, 32]. However, the histologic factors and mechanisms leading from gastritis to ulcer or cancer are poorly known. Gastritis activity and HP-linked surface epithelium lesions have been suggested to play some role in ulcerogenesis [7, 9, 12, 13, 15, 34] while intestinal metaplasia (IM) has long been indicated as a factor in cancerogenesis [6, 21, 22].


Peptic Ulcer Duodenal Ulcer Intestinal Metaplasia Chronic Gastritis Nonulcer Dyspepsia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • E. Solcia
    • 1
    • 2
  • R. Fiocca
    • 1
  • L. Villani
    • 2
  • O. Luinetti
    • 2
  • A. Gianatti
    • 2
  • E. Trespi
    • 3
  • G. Stella
    • 4
  • M. Cornaggia
    • 5
  • A. Chiaravalli
    • 5
  • C. Capella
    • 5
    • 6
  1. 1.Department of PathologyUniversity of PaviaItaly
  2. 2.Pathology ServiceIRCCS Policlinico San MatteoPaviaItaly
  3. 3.Digestive Physiopathology CenterIRCCS Policlinico San MatteoPaviaItaly
  4. 4.Pathology ServiceGeneral HospitalVogheraItaly
  5. 5.Pathology ServiceGeneral HospitalVareseItaly
  6. 6.Department of PathologyUniversity of PaviaVareseItaly

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