Colorimetric Evaluation of the Human Skin Blanching Assay

  • C. Queille-Roussel
  • L. Duteil
  • J. Czernielewski
  • H. Schaefer


Normal skin color changes occur as consequences of either vascular or pigmentary modifications. Up to now, skin color modifications were usually assessed using various arbitrary visual scales. Numerous attempts to objectively quantity such modifications were performed. Thus, erythema caused by dermal vasodilation can be evaluated by either laser Doppler velocimetry [1] or spectrophotometry [2] However, vasoconstriction-induced blanching and disturbances of the melanin system (hypermelanosis, e. g., tanning, and hypo-, or amelanosis, e. g., nevus depigmentosa, vitiligo,) have remained difficult to quantity objectively.


Visual Score Clobetasol Propionate Base Cream Betamethasone Dipropionate Untreated Site 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • C. Queille-Roussel
    • 1
  • L. Duteil
    • 1
  • J. Czernielewski
    • 1
  • H. Schaefer
    • 2
  1. 1.Centre International de Recherches Dermatoloques Galderma (CIRD Galderma)ValbonneFrance
  2. 2.Centre de Pharmacologie Clinique Appliquée a la Dermatologie (CPCAD)Hôpital PasteurNiceFrance

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